Surgery

Dentistry

Physics

Denosumab

Optics

Internal medicine

Odds ratio

Oncology

Medicine

Bisphosphonate

Zoledronic acid

Incidence (geometry)

Osteonecrosis of the jaw

Cancer

Randomized controlled trial

Osteoporosis

Medicina oral, patología oral y cirugía bucal

Background: The aim of the present study was to analyse the incidence, risk ratio (RR) and prognoses of two types of medication-related osteonecrosis of the jaws (MRONJ): denosumab-related osteonecrosis of the jaws (DRONJ) and Bisphosphonate-Related Osteonecrosis of the Jaws (BRONJ) in cancer patients under treatment with denosumab or zoledronic acid (ZA).Material and Methods: An electronic and manual search was conducted for randomized controlled trials (RCTs) until May 2019.Assessment of the identified studies, risk of bias and data extraction were performed independently by two reviewers.The incidence of DRONJ and BRONJ and the RR to develop MRONJ were calculated at 1 year, 2 years and 3 years of exposure.It was also calculated the odds ratio (OR) of their respective prognoses.They were calculated normalizing the values of the individual studies to 1 year, 2 years or 3 years when necessary through robust regression models using a statistical program.Results: From 1.277 references identified, 8 RCTs were included, which comprised a total of 13.857 patients with a variety of neoplasms.The incidence of DRONJ in cancer patients under treatment with denosumab ranged from 0.5 to 2.1% after 1 year, 1.1 to 3.0% after 2 years, and 1.3 to 3.2% after 3 years of exposure.The incidence of BRONJ in cancer patients under treatment with ZA ranged from 0.4 to 1.6% after 1 year of exposure, 0.8 to

Medication-related osteonecrosis of the jaws (MRONJ) in cancer patients treated with denosumab VS. zoledronic acid: A systematic review and meta-analysis