Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
Abstract
Naïve CD4 + T cells coordinate the immune response by acquiring an effector phenotype in response to cytokines. However, the cytokine responses in memory T cells remain largely understudied. Here we use quantitative proteomics, bulk RNA-seq, and single-cell RNA-seq of over 40,000 human naïve and memory CD4 + T cells to show that responses to cytokines differ substantially between these cell types. Memory T cells are unable to differentiate into...
Paper Details
Title
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
Published Date
Apr 14, 2020
Journal
Volume
11
Issue
1
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