Abstract The antibiotics-independent antimicrobial activity of graphene oxide (GO) is of great importance since antibiotic therapy is facing great challenges from drug resistance. However, the relations of GO size with its antimicrobial activity and how the size regulates the antibacterial mechanisms are still unknown. Herein, we fabricated four GO suspensions with different sizes and demonstrated the parabolic relationship between GO size and its antibacterial activity against the Gram-positive cariogenic bacterium Streptococcus mutans. More interestingly, we found out how GO size regulated the nano-bio interaction-based physical antibacterial mechanisms. Increasing the size reduced the cutting effect but enhanced the cell entrapment effect, and vice versa. In conclusion, GO size affects its edge density and lateral dimension, further regulates its physical antibacterial mechanisms in different orientations and ultimately determines its activity. These findings provide a deep understanding of GO antibacterial property and may guide the design and development of GO for clinical use.
Last. Huang Pei(HEU: Harbin Engineering University)H-Index: 1
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Abstract In order to improve the anti-biofouling performance of ultrafiltration membrane, quaternized graphene oxide (QGO) was synthesized as a membrane modifier by in-situ growth of quaternary ammonium salt on the graphene oxide surface. A hydrophilic and antibacterial dual functional membrane was prepared with this kind of modifiers by immersion phase inversion method. The modified membrane obviously exhibits enhanced hydrophilicity, antibacterial and mechanical properties than the unmodified ...
#1Rong Cai(CAS: Chinese Academy of Sciences)H-Index: 10
#2Chunying Chen(CAS: Chinese Academy of Sciences)H-Index: 101
: Engineering nanomaterials are increasingly considered promising and powerful biomedical tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials have been tested in clinical trials. This wide gap between bench discoveries and clinical application is mainly due to the limited understanding of the biological identity of nanomaterials. When they are exposed to the human body, nanoparticles inevitably interact with bodily fluids and thereby adsorb hundreds of biomol...
Last. Lobat Tayebi(Marquette University)H-Index: 42
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Abstract The emerging science of graphene-based engineered nanomaterials as either nanomedicines or dental materials in dentistry is growing. Apart from its exceptional mechanical characteristics, electrical conductivity and thermal stability, graphene and its derivatives can be functionalized with several bioactive molecules, allowing them to be incorporated into and improve different scaffolds used in regenerative dentistry. This review presents state of the art graphene-based engineered nanom...
#1Xin Zhao(Soochow University (Suzhou))H-Index: 45
Last. Yuanjin Zhao(SEU: Southeast University)H-Index: 55
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: Intelligent responsive microcarriers have emerged as a promising class of biomaterials for therapeutic delivery and tissue regeneration, since they can respond to external stimuli and release the loaded drugs in an active manner. Among various available stimuli, near-infrared (NIR) light is particularly attractive because it can penetrate biotic tissues with sufficient intensity and minimal damage. In this work, a kind of photoresponsive delivery microcarriers (PDMs) is developed using microfl...
Abstract Graphene-based nanomaterials, such as graphene oxide (GO) and reduced graphene oxide (rGO), have shown great potentials in drug delivery and photodynamic/photothermal therapy due to their featured structure and physicochemical properties. In recent years, their antibacterial potentials have also been exploited. The commonly recognized antibacterial mechanisms include sharp edge-mediated cutting effect, oxidative stress and cell entrapment. This antibacterial activity is very important f...
The worldwide emergence of microbial resistance to antibiotics constitutes an important and growing public health threat, and novel antibiotics are urgently needed. In this report, a series of symmetrical membrane-active agents linked by an aromatic nucleus were designed and synthesized. Some showed high antibacterial activity against clinical drug-resistant bacterial isolates including methicillin-resistant Staphylococcus aureus (MRSA), carbapenemase-producing Enterobacter aerogenes, and delhi ...
#1Didar Baimanov(CAS: Chinese Academy of Sciences)H-Index: 4
#2Rong Cai(Center for Excellence in Education)H-Index: 10
Last. Chunying Chen(CAS: Chinese Academy of Sciences)H-Index: 101
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The formation of a protein corona has been considered a pitfall in the clinical translation of nanomedicines. Hence, interdisciplinary studies on corona characterization are critically essential. A deep understanding of the formation of hard and soft protein coronas upon in vivo administration of nanoparticles is vital. The protein corona gives the nanoplatform a new biological identity. Furthermore, the control of and mechanistic understanding of corona formation as it is regulated by the physi...
Last. Yuxia Luan(SDU: Shandong University)H-Index: 31
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Abstract Graphene oxide (GO), as a drug delivery carrier, has attracted considerable attention because of its interesting properties. However, GO tends to aggregate in aqueous solution. Amphiphilic molecules are usually necessary to stabilize GO. The introduction of these non-functional macromolecules on the one hand reduces drug loading, but on the other hand may cause unpredictable side effects. This study proposes a new strategy for stabilizing GO with a functional photothermal agent, IR820 (...
#1Yaling Wang(Center for Excellence in Education)H-Index: 4
#1Yaling Wang(Center for Excellence in Education)H-Index: 22
Last. Chunying Chen(CAS: Chinese Academy of Sciences)H-Index: 101
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ConspectusEngineered nanomaterials (ENMs) have been developed for imaging, drug delivery, diagnosis, and clinical therapeutic purposes because of their outstanding physicochemical characteristics. However, the function and ultimate efficiency of nanomedicines remain unsatisfactory for clinical application, mainly because of our insufficient understanding of nanomaterial/nanomedicine–biology (nano–bio) interactions. The nonequilibrated, complex, and heterogeneous nature of the biological milieu i...
: In the past decades, nanomaterials have shown great potential in biomedical fields, especially in drug delivery, imaging and targeted therapy. Recently, the development of novel functional nanomaterials for antibacterial application has attracted much attention. Compared to the traditional direct use of antibiotics, antibacterial nanomaterials either as drug delivery systems or active agents have a higher efficacy and lower side effects. Herein, we will focus on the antibacterial applications ...
Graphene, a two dimensional (2D) layered material has attracted much attention from the scientific community due to its exceptional electrical, thermal, mechanical, biomedical and optical properties. Hence, numerous applications utilizing graphene-based materials could be conceived in the next generation electronics, chemical and biological sensing, energy conversion and storage, and beyond. Interaction between graphene surfaces with other materials, plays a vital role in influencing its propert...
Abstract In most cases, once nanoparticles (NPs) enter the blood, their surface is covered by biological molecules, especially proteins, forming a so-called protein corona (PC). As a result, what the cells of the body “see” is not the NPs as formulated by the chemists, but the PC. In this way, the PC can influence the effects of the NPs and even mask the desired effects of the NP components. While this can argue for trying to inhibit protein-nanomaterial interactions, encapsulating NPs in an end...
Last. Weiwei Zhang(AHPU: Anhui Polytechnic University)H-Index: 1
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Background With the development of bacterial resistance, the range of effective antibiotics is increasingly becoming more limited. The effective use of nanoscale antimicrobial peptides (AP) in therapeutic and diagnostic methods is a strategy for new antibiotics. Methods Combining both AP and cadmium selenide (CdSe) into a composite material may result in a reagent with novel properties, such as enhanced antibacterial activity, fluorescence and favorable stability in aqueous solution. Results AP-...
Abuse of antibiotics has led to the emergence of drug-resistant pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) was reported just two years after the clinical use of methicillin, which can cause severe infections with high morbidity and mortality in both community and hospital. The treatment of MRSA infection is greatly challenging since it has developed the resistance to almost all types of antibiotics. As such, it is of great significance and importance to develop novel therapeut...
Abstract The antimicrobial activity of graphene-based nanomaterials (GBNs) has recently gained significant attention in numerous biomedical science applications. GBNs exhibit excellent antimicrobial properties and have been adopted as antimicrobial nanomaterials due to their abilities to disrupt the integrity of bacterial cell membrane and produce reactive oxygen species (ROS). This review discussed the various mechanisms of GBNs' antimicrobial effects and factors underlying GBNs' antimicrobial ...
Abstract A set of thirteen GO samples obtained following different methodologies and described by eight structural parameters - hydrodynamic diameter (658 nm - 142 nm), size polydispersity index, optical absorption coefficient, lambda maximum, D/G peak intensity ratio, crystallite size, distance between defects, and pH - was submitted to NIR 808 nm irradiation (experiment 1) and fish embryo toxicity (FET) test performed with zebrafish embryos (experiment 2). Principal component analysis (PCA) ap...
Abstract Graphene and its derivatives are promising candidates for a variety of biological applications, among which, their anti-pathogenic properties are highly attractive due to the outstanding physicochemical characteristics of these novel nanomaterials. The antibacterial, antiviral and antifungal performances of graphene are increasingly becoming more important due to the pathogen's resistance to existing drugs. Despite this, the factors influencing the antibacterial activity of graphene nan...
Abstract Polydopamine (PDA) has shown great potentials in biomedical fields due largely to its unique physicochemical properties, including high photothermal transfer efficiency, excellent drug binding capacity, versatile adhesion ability, sensitive pH responsibility and great biocompatibility and biodegradability. These properties confer PDA-based nanoparticles the potentials either as the drug carriers for advanced drug delivery or as the bioactive agents for photothermal therapy, imaging and ...
Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for mali...
Last. Shaohuang Weng(Fujian Medical University)H-Index: 17
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Abstract Widespread bacterial infection and the spread of antibiotic resistance exhibit increasing threat to the public and thus require new antibacterial strategies. Carbon quantum dots (CQDs) have been extensively investigated to play fluorescent, catalytic roles and even potential biomedical functions containing sterilization. However, synthetic understanding of the interaction of CQDs and bacteria, the exhibition of antibacterial ability, and the risk of resistance evolution remain lacking. ...