Abstract The surface modification of biomaterials is crucial for constructing bioactive interfaces capable of interacting with specific biomolecules, controlling cell behavior and regulating biological processes. Because of their excellent biocompatibility, facile preparation, pH-responsiveness and universal adhesion, surface coatings made from metal–phenolic network (MPN) have attracted extensive attention for handling interfacial properties and designing biomaterials in recent years. Different...
Last. Luciano Caseli(UNIFESP: Federal University of São Paulo)H-Index: 26
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Abstract Gold nanoparticles have been intensively studied in cancer therapy to improve drug release, increasing therapeutic action and reducing adverse effects. The interaction between gold nanoparticles and cell membranes can give information about the cell internalization. In this study, gold nanoparticles with aminolevulinic acid (5-ALA) were synthesized using the photoreduction method (5-ALA: AuNPs). The prodrug 5-ALA is responsible for protoporphyrin IX synthesis inside the cell and allows ...
Last. Wang Yangguang(ZJOU: Zhejiang Ocean University)H-Index: 12
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Abstract This study aimed to use xanthan gum as a stabilizer to improve the stability of zein nanoparticles. Zein-xanthan gum composite nanoparticles were prepared via anti-solvent precipitation at pH 4.0. The particle size, zeta potential, and stability of the system were related to the amount of xanthan gum added. When 20 mg of xanthan gum was added, spherical nanoparticles with a small particle size (179 ± 2.1 nm) and sufficient negative zeta potential (−42 ± 1.6 mV) were obtained. The zeta p...
#1Yiqian Huang(Huada: Beijing University of Chemical Technology)H-Index: 7
#2Wei Jing(Huada: Beijing University of Chemical Technology)H-Index: 7
Last. Xiaoping Yang(Huada: Beijing University of Chemical Technology)H-Index: 54
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Abstract Bone is an electrically responsive tissue, so electroactive materials that can deliver electrical cues to bone are helpful for enhancing regeneration under electrical stimulation (ES), and conductive materials are crucial in ES transmission to determine osteogenesis. Compared with polyesters, biodegradable polyorganophosphazenes (POPPs) show superiority in the field of bone tissue engineering thanks to their rich phosphorus/nitrogen contents, suggesting that the combination of POPPs-bas...
Abstract Here, a chimeric bifunctional enzyme was developed for two activities xylanase and deacetylase. Chimeric enzyme was designed by combining the relevant amino acid stretches from two different parent sequences, such as polysaccharide/xylan deacetylase (ref id: MT682066) and xylanase (ref id WP_110897546.1). Five different hypothetical chimeras were developed and one of the best predicted chimeric protein GA_2(syn_SKYAP01) was synthesized. The GA_2(syn_SKYAP01) possessed the specific activ...
Abstract In this study, surficial interactions of glutaraldehyde (GA) as an important crosslinker agent with the β-glucosidase (BGL) enzyme surface were investigated by theoretical methods. Since the inherent constraints of experimental methods limit their application to find the molecular perspective of these significant interactions in enzyme immobilization, theoretical methods were used as a complementary tool to understand this concept. The Minnesota density functional calculations showed th...
As a fascinating class of fluorescent carbon dots (CDs), doped-CDs are now sparked intense research interest, particularly in the diverse fields of biomedical applications due to their unique advantages, including low toxicity, physicochemical, photostability, excellent biocompatibility, and so on. In this review, we have summarized the most recent developments in the literature regarding the employment of doped-CDs for pharmaceutical and medical applications, which are published over approximat...
#1Xi Chen(National Institute for Materials Science)H-Index: 3
#2Tetsushi Taguchi(National Institute for Materials Science)H-Index: 24
Adhesive bone pastes for dental implants and soft tissue interfaces were developed using α-tricalcium phosphate (α-TCP) and α-cyclodextrin (α-CD)/nonanyl group-modified poly(vinyl alcohol) (C9-PVA) inclusion complex solution (ICS). The thixotropic solution of α-CD/C9-PVA ICS was prepared by mixing α-CD and C9-PVA in deionized water. The α-CD/C9-PVA bone paste led to the highest bonding and shear adhesion between commercial pure titanium plates and soft tissue like collagen casing. Moreover, the ...
#2Hyun Wook Kang(Pukyong National University)H-Index: 17
Abstract The present study aims to evaluate the synthesis of nanohydroxyapatite/collagen-loaded fucoidan-based composite hydrogel and characterized its physico-chemical properties for targeted drug delivery to gastrointestinal cancer cells. The nanomaterial is fabricated and characterized as small spherical nanosheets with a high thermal stability by using Fourier transform infrared (FTIR) analysis, X-ray diffraction (XRD), Thermogravimetric analysis (TGA), UV–vis spectrophotometry (UV–vis), sca...
Abstract Harvesting the low molecular weight (LMW) proteins from the cellular exudates is a big challenge for early disease detection. Here, we introduce a unique probe composed of surface-functionalized Fe2C NPs with different functional groups to harvest, identify and profile differentially expressed biomarker proteins. Three different functionalization of Fe2C NPs with Fe2C@NH2, Fe2C@COOH and Fe2C@PEG enabled to harvest 119 differentially expressed proteins from HeLa cell exudates. Among thes...