Light‐Activated Protein Conjugation and 89Zr‐Radiolabelling with Water‐Soluble Desferrioxamine Derivatives
Abstract
Protein-conjugates are vital tools in biomedical research, drug discovery and imaging science. For example, functionalised monoclonal antibodies (mAbs) coupled to the desferrioxamine B (DFO) chelate and radiolabelled with 89 Zr4+ ions are used as radiopharmaceuticals for diagnostic positron emission tomography (PET). In this context, protein functionalisation requires the formation of a covalent bond that must be achieved without compromising...
Paper Details
Title
Light‐Activated Protein Conjugation and 89Zr‐Radiolabelling with Water‐Soluble Desferrioxamine Derivatives
Published Date
May 4, 2020
Volume
26
Issue
32
Pages
7185 - 7189
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