Original paper

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

Cell45.50
Volume: 181, Issue: 4, Pages: 894 - 904.e9
Published: May 1, 2020
Abstract
The recent emergence of a novel coronavirus (SARS-CoV-2) in China has caused significant public health concerns. Recently, ACE2 was reported as an entry receptor for SARS-CoV-2. In this study, we present the crystal structure of the C-terminal domain of SARS-CoV-2 (SARS-CoV-2-CTD) spike (S) protein in complex with human ACE2 (hACE2), which reveals a hACE2-binding mode similar overall to that observed for SARS-CoV. However, atomic details at the...
Paper Details
Title
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
Published Date
May 1, 2020
Journal
Volume
181
Issue
4
Pages
894 - 904.e9
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