Undefined/non-malignant hepatic nodules are associated with early occurrence of HCC in DAA-treated patients with HCV-related cirrhosis

•The study focuses on the risk of developing de novo or recurrent HCC after DAA treatment in patients with HCV cirrhosis. •An early peak of HCC incidence was observed in DAA-treated patients. •Undefined non-malignant nodules, ascites and AFP were independently associated with the incidence of de novo HCC. •History of alcohol abuse and history of previous HCC recurrence were associated with HCC recurrence. •No evidence of increased tumour...