Combining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma

In colorectal and breast cancer, the density and localisation of immune infiltrates provides strong prognostic information. We asked whether similar automated quantitation and combined analysis of immune infiltrates could refine prognostic information in high-grade serous ovarian carcinoma (HGSOC) and tested associations between patterns of immune response and genomic driver alterations.Epithelium and stroma were semi-automatically segmented and...