Papillary thyroid microcarcinoma presenting as a metastasis to the brain

Published on Apr 1, 2020in Annals of The Royal College of Surgeons of England1.891
· DOI :10.1308/RCSANN.2020.0041
Michael S. Shawky7
Estimated H-index: 7
(Alexandria University),
Ian Proctor10
Estimated H-index: 10
(UCLH: University College Hospital)
+ 1 AuthorsTarek Ezzat Abdel-Aziz6
Estimated H-index: 6
(Alexandria University)
Sources
Abstract
The brain is a particularly rare site of metastasis from papillary microcarcinoma, with only few cases described in the literature. We present a case of 59-year-old man who presented with seizures ...
References19
Newest
#1Nikola Slijepcevic (University of Belgrade)H-Index: 8
#2Vladan Zivaljevic (University of Belgrade)H-Index: 19
Last. Ivan Paunovic (University of Belgrade)H-Index: 18
view all 6 authors...
Purpose The aims of this study were to investigate the rate of intrathyroid extension of papillary thyroid microcarcinoma (PTMC) in patients operated for benign thyroid disease and to identify independent risk factors associated with it.
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#1Yanan Xu (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Le Xu (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Jiadong Wang (SJTU: Shanghai Jiao Tong University)H-Index: 6
view all 3 authors...
Abstract Background The treatment of papillary thyroid microcarcinoma (PTMC) patients is controversial, as PTMC is often found incidentally and its prognosis is quite good. Because lymph node metastasis (LNM) is one of the main predictors of recurrence and impacts the survival rate of PTMC patients, this study aims to retrospectively identify the clinical factors that increase the risk of LNM and/or recurrence and can then be used to separate clinically unfavorable PTMCs from the rest and to hel...
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#1Nori L. Bradley (UBC: University of British Columbia)H-Index: 7
#2Sam M. Wiseman (UBC: University of British Columbia)H-Index: 36
Abstract Background Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small ( Methods Amongst 1459 sequential patients undergoing thyroid surgery at a single center, 132 (9%) cases were diagnosed with PTM. We performed a retrospective analysis of these cases using Fisher’s Exact Test...
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#1Maria Annateresa Provenzale (UniPi: University of Pisa)H-Index: 5
#2Emilio Fiore (UniPi: University of Pisa)H-Index: 22
Last. Paolo Vitti (UniPi: University of Pisa)H-Index: 72
view all 9 authors...
OBJECTIVE: Papillary thyroid microcarcinomas (microPTC) may be 'incidental' (Inc-microPTC), occasionally found at histology after surgery for benign disease or 'non-incidental' (Non-Inc-microPTC), diagnosed on clinical grounds. It is unclear whether these different microPTC reflect the same disease. The aim of the study was to compare Inc-microPTC and Non-Inc-microPTC for clinical and histological features as well as for serum TSH, a known factor involved in PTC development. DESIGN: We evaluated...
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#1JeonMin Ji (UOU: University of Ulsan)H-Index: 3
#2KimWon Gu (UOU: University of Ulsan)H-Index: 3
Last. KimWon Bae (UOU: University of Ulsan)H-Index: 3
view all 13 authors...
Background: The recent increase in the incidence of thyroid cancer has been mainly attributed to papillary thyroid microcarcinomas (PTMCs), and many studies have suggested conservative strategies for the diagnosis and treatment of PTMC. However, PTMCs may be associated with distant metastasis. This study aimed to evaluate the clinicopathological features and identify the risk factors for distant metastasis in patients with PTMCs. Methods: The medical records of 8808 patients who were diagnosed w...
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Papillary carcinoma is the most common thyroid malignancy. Many variants of this tumor have been described, with different morphological and molecular characteristics. Although most cases have excellent prognosis, the relationship between tumor architecture and its biological behavior remains controversial. OBJECTIVE: To present the experience of a single center on the prevalence of thyroid papillary carcinoma variants and their relationship with other histopathological prognostic factors. METHO...
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#2Annelise KrogdahlH-Index: 28
Last. Christian GodballeH-Index: 30
view all 10 authors...
Background: With an observed general rise in papillary thyroid carcinoma incidence, papillary microcarcinoma (PMC) is accordingly found more frequently and often incidentally by histological examination of surgical specimens from presumed benign thyroid disease. Only a few studies have specifically addressed the prognosis of incidentally found PMC, and they have been limited to retrospective single-center studies. Methods: This was a national, unselected, prospective cohort study of 406 papillar...
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#3Rebecca S. Sippel (UW: University of Wisconsin-Madison)H-Index: 24
Objective:The purpose of this study was to identify the risk factors that predict papillary thyroid microcarcinoma (PTMC)-related death in a large patient population to determine which patients need aggressive treatment.Background:The management of PTMC is controversial and ranges from observation t
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#1Yan-Hong XuH-Index: 6
#2Hong-Jun SongH-Index: 15
Last. Quan-Yong LuoH-Index: 21
view all 4 authors...
: We present three papillary thyroid carcinoma PTC patients with brain metastases who are unusual in many aspects. The first case is a unique 3mm papillary thyroid microcarcinoma (PTMC) patient with metastases to the cerebrum and lung. The solitary cerebral lesion was identified by iodine-131 whole- body scan ((131)I-WBS) and (131)I single photon emission tomography/computed tomography (SPET/CT). Almost complete response achieved after radiosurgery. The second case is a unique PTC patient with c...
#1Beatriz LecumberriH-Index: 14
Last. Luis Felipe PallardoH-Index: 16
view all 8 authors...
Background: Cerebellar metastasis (CM) from papillary thyroid carcinoma (PTC) is exceptional with only 12 reported cases and usually carries a very poor prognosis. In the two previously reported patients in whom CM was detected before PTC, other distant or local metastases were already present by the time of PTC diagnosis. We report a patient found to have papillary thyroid microcarcinoma after surgical resection and histopathological study of a large solitary hemorrhagic CM, who showed no evide...
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Cited By1
Newest
#1Krzysztof Kaliszewski (Wrocław Medical University)H-Index: 11
#2Dorota Diakowska (Wrocław Medical University)H-Index: 16
Last. Jerzy Rudnicki (Wrocław Medical University)H-Index: 8
view all 8 authors...
BACKGROUND Currently, less aggressive treatment or even active surveillance of papillary thyroid microcarcinoma (PTMC) is widely accepted and recommended as a therapeutic management option. However, there are some concerns about these approaches. We investigated whether there are any demographic, clinical and ultrasound characteristics of PTMC patients that are easy to obtain and clinically available before surgery to help clinicians make proper therapeutic decisions. METHODS We performed a retr...
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