Myofibroblast-Derived Exosomes Contribute to Development of a Susceptible Substrate for Atrial Fibrillation
Abstract
<b><i>Objective:</i></b> Atrial fibrosis plays a critical role in atrial fibrillation (AF). A key event in the pathogenesis of fibrosis is the activation of fibroblasts (FBs) into myofibroblasts (MFBs). Paracrine factors released from MFBs lead to ion channel expression changes in cardiomyocytes (CMs). Downregulation of L-type calcium channel Ca<sub>v</sub>1.2 expression is a hallmark of AF-associated ionic...
Paper Details
Title
Myofibroblast-Derived Exosomes Contribute to Development of a Susceptible Substrate for Atrial Fibrillation
Published Date
Jan 1, 2020
Journal
Volume
145
Issue
5
Pages
324 - 332
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Notes
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