Biology

Biochemistry

Botany

Fungus

Stereochemistry

Cytotoxicity

Polymer

Organic chemistry

In vitro

Absolute configuration

Chemistry

Monomer

Journal of Natural Products

Dipleosporalones A and B (1 and 2), two new [2 + 2] azaphilone dimers, were obtained from a marine-derived Pleosporales sp. fungus. The absolute configurations of 1 and 2 were elucidated by calculations of their ECD spectra. Dipleosporalone A (1) possessed an unprecedented skeleton with an uncommon 6/4/6 ring system. Compounds 1 and 2 showed cytotoxicity about 30–90-fold more potent than that of their monomer pinophilin B.

Dipleosporalones A and B, Dimeric Azaphilones from a Marine-Derived <i>Pleosporales</i> sp. Fungus

Dipleosporalones A and B, Dimeric Azaphilones from a Marine-Derived Pleosporales sp. Fungus