Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers.

Published on Apr 3, 2020in JAMA Cardiology12.794
· DOI :10.1001/JAMACARDIO.2020.1282
Chirag Bavishi25
Estimated H-index: 25
(Brown University),
Thomas M. Maddox54
Estimated H-index: 54
(WashU: Washington University in St. Louis),
Franz H. Messerli49
Estimated H-index: 49
(ISMMS: Icahn School of Medicine at Mount Sinai)
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Abstract
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Background: Acute respiratory distress syndrome (ARDS) remains a life-threatening disease. Many patients with ARDS do not recover fully, and progress to terminal lung fibrosis. Angiotensin-converting enzyme (ACE) inhibitor is known to modulate the neurohormonal system to reduce inflammation and to prevent tissue fibrosis. However, the role of ACE inhibitor in the lungs is not well understood. We therefore conducted this study to elucidate the effect of renin-angiotensin system (RAS) blockage on ...
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Since the identification of the alternative angiotensin converting enzyme (ACE)2/Ang-(1-7)/Mas receptor axis, renin-angiotensin system (RAS) is a new complex target for a pharmacological intervention. We investigated the expression of RAS components in the heart and kidney during the development of hypertension and its perinatal treatment with losartan in young spontaneously hypertensive rats (SHR). Expressions of RAS genes were studied by the RT-PCR in the left ventricle and kidney of rats: nor...
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