Modulating the Distant Spreading of Patient-Derived Colorectal Cancer Cells via Aspirin and Metformin
Abstract
Although screening has reduced mortality rates for colorectal cancer (CRC), about 20% of patients still carry metastases at diagnosis. Postsurgery chemotherapy is toxic and induces drug resistance. Promising alternative strategies rely on repurposing drugs such as aspirin (ASA) and metformin (MET). Here, tumor spheroids were generated in suspension by primary CRCs and metastatic lymph nodes from 11 patients. These spheroids presented a...
Paper Details
Title
Modulating the Distant Spreading of Patient-Derived Colorectal Cancer Cells via Aspirin and Metformin
Published Date
Apr 1, 2020
Journal
Volume
13
Issue
4
Pages
100760 - 100760
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