Performance of clinicopathologic models in men with high risk localized prostate cancer: impact of a 22-gene genomic classifier

Prostate cancer exhibits biological and clinical heterogeneity even within established clinico-pathologic risk groups. The Decipher genomic classifier (GC) is a validated method to further risk-stratify disease in patients with prostate cancer, but its performance solely within National Comprehensive Cancer Network (NCCN) high-risk disease has not been undertaken to date.A multi-institutional retrospective study of 405 men with high-risk...