Antimicrobial use and resistance in food-producing animals and the environment: an African perspective.

Published on Mar 3, 2020in Antimicrobial Resistance and Infection Control3.594
· DOI :10.1186/S13756-020-0697-X
Zuhura I. Kimera2
Estimated H-index: 2
(MUHAS: Muhimbili University of Health and Allied Sciences),
Stephen E. Mshana28
Estimated H-index: 28
(Catholic University of Health and Allied Sciences)
+ 2 AuthorsMecky I. Matee3
Estimated H-index: 3
(SUA: Sokoine University of Agriculture)
Sources
Abstract
BACKGROUND: The overuse of antimicrobials in food animals and the subsequent contamination of the environment have been associated with development and spread of antimicrobial resistance. This review presents information on antimicrobial use, resistance and status of surveillance systems in food animals and the environment in Africa. METHODS: Information was searched through PubMed, Google Scholar, Web of Science, and African Journal Online databases. Full-length original research and review articles on antimicrobial use, prevalence of AMR from Africa covering a period from 2005 to 2018 were examined. The articles were scrutinized to extract information on the antimicrobial use, resistance and surveillance systems. RESULTS: A total of 200 articles were recovered. Of these, 176 studies were included in the review while 24 articles were excluded because they were not relevant to antimicrobial use and/or resistance in food animals and the environment. The percentage of farms using antimicrobials in animal production ranged from 77.6% in Nigeria to 100% in Tanzania, Cameroon, Zambia, Ghana and Egypt. The most antibiotics used were tetracycline, aminoglycoside and penicillin groups. The percentage of multi drug resistant isolates ranged from 20% in Nigeria to 100% in South Africa, Zimbabwe and Tunisia. In the environment, percentage of multi drug resistant isolates ranged from 33.3% in South Africa to 100% in Algeria. None of the countries documented national antimicrobial use and resistance surveillance system in animals. CONCLUSION: There is high level of antimicrobial use, especially tetracycline, aminoglycoside and penicillin in animal production systems in Africa. This is likely to escalate the already high prevalence of antimicrobial resistance and multi drug resistance in the continent. This, coupled with weak antimicrobial resistance surveillance systems in the region is a great concern to the animals, environment and humans as well.
📖 Papers frequently viewed together
33 Citations
160 Citations
References96
Newest
#1Don A. Moore (University of California, Berkeley)H-Index: 53
#2Derek Schatz (Accenture)H-Index: 1
Overconfident people should be surprised that they are so often wrong. Are they? Three studies examined the relationship between confidence and surprise in order to shed light on the psychology of overprecision in judgment. Participants reported ex-ante confidence in their beliefs, and after receiving accuracy feedback, they then reported ex-post surprise. Results show that more ex-ante confidence produces less ex-post surprise for correct answers; this relationship reverses for incorrect answer...
1 CitationsSource
#1Takele Beyene Tufa (AAU: Addis Ababa University)H-Index: 4
#2Feraol Gurmu (AAU: Addis Ababa University)H-Index: 1
Last. Jan Arend Stegeman (UU: Utrecht University)H-Index: 38
view all 10 authors...
Background Antimicrobials and anthelmintics are the most commonly used veterinary drugs to control animal diseases. However, widespread use of these drugs could contribute to the emergence of drug resistance. Information on the practice of antimicrobial usage among food animal raising communities in Central Ethiopia is scarce. We used a standardised questionnaire survey to assess knowledge, awareness, and practices related to drug use and resistance in food animals among the farmers in and aroun...
9 CitationsSource
#1N.B. Alhaji (UI: University of Ibadan)H-Index: 6
#2Tajudeen Opeyemi Isola (UI: University of Ibadan)H-Index: 5
Abstract Antimicrobials are used to maintain good health and productivity of food animals. Misuse of antibiotics in livestock contributes to development of antimicrobial resistance, an emerging One Health issue. This study assessed pastoralists' knowledge and practices regarding antimicrobial usage, explore pathways for resistant pathogens emergence and associated social drivers for antimicrobial misuse in pastoral herds of North-central Nigeria. An interview questionnaire-based cross-sectional ...
18 CitationsSource
#1Mutshiene Deogratias Ekwanzala (TUT: Tshwane University of Technology)H-Index: 5
#2John Barr Dewar (UNISA: University of South Africa)H-Index: 12
Last. Maggy Ndombo Benteke Momba (TUT: Tshwane University of Technology)H-Index: 29
view all 4 authors...
: A systematic review was conducted to determine the distribution and prevalence of antibiotic-resistant bacteria (ARB), antimicrobial-resistant genes (ARGs), and antimicrobial-resistant gene determinants (ARGDs) in clinical, environmental, and farm settings and to identify key knowledge gaps in a bid to contain their spread. Fifty-three articles were included. The prevalence of a wide range of antimicrobial-resistant bacteria and their genes was reviewed. Based on the studies reviewed in this s...
24 CitationsSource
#1Kennedy F. Chah (UNN: University of Nigeria, Nsukka)H-Index: 12
#2Ifeoma Chinyere Ugwu (UNN: University of Nigeria, Nsukka)H-Index: 4
Last. Carmen Torres (UR: University of La Rioja)H-Index: 74
view all 8 authors...
Abstract Objectives This study screened chickens and pigs slaughtered for human consumption for the presence and characteristics of extended-spectrum β-lactamase (ESBL)- and plasmid-encoded AmpC (pAmpC) β-lactamase-producing enteric bacteria. Methods Faecal samples from 410 broiler chickens and 100 pigs were cultured on MacConkey agar supplemented with 2 μg/mL cefotaxime. Antimicrobial resistance phenotypes of the recovered isolates were determined by disk diffusion. PCR and sequencing were perf...
13 CitationsSource
#1Kingsley Ehi Ebomah (University of Fort Hare)H-Index: 2
#2Martins Ajibade Adefisoye (University of Fort Hare)H-Index: 7
Last. Anthony I. Okoh (University of Fort Hare)H-Index: 58
view all 3 authors...
The prevalence of pathogenic microorganisms, as well as the proliferation of antimicrobial resistance, pose a significant threat to public health. However, the magnitude of the impact of aquatic environs concerning the advent and propagation of resistance genes remains vague. Escherichia coli (E. coli) are widespread and encompass a variety of strains, ranging from non-pathogenic to highly pathogenic. This study reports on the incidence and antibiotic susceptibility profiles of E. coli isolates ...
9 CitationsSource
#1Hao Zhang (MUC: Minzu University of China)H-Index: 3
#2Ling Yang (HIT: Harbin Institute of Technology)H-Index: 7
Last. Rong-Zhen Liao (HUST: Huazhong University of Science and Technology)H-Index: 26
view all 6 authors...
The calcium-dependent β-propeller proteins mammalian serum paraoxonase 1 (PON1) and phosphotriesterase diisopropyl fluorophosphatase (DFPase) catalyze the hydrolysis of organophosphorus compounds and enhance hydrolysis of various nerve agents. In the present work, the phosphotriesterase activity development between PON1 and DFPase was investigated by using the hybrid density functional theory method B3LYP. Based on the active-site difference between PON1 and DFPase, both the wild type and the mu...
402 CitationsSource
#1Nurudeen Olalekan Oloso (University of Pretoria)H-Index: 3
#2Shamsudeen F. FagboH-Index: 12
Last. Folorunso Oludayo Fasina (University of Pretoria)H-Index: 22
view all 9 authors...
Supplementary Materials Figure S1: Flow chart of the methodological strategy (PRISMA 2009 Flow Diagram), Figure S2: Nigeria geopolitical zonal spread of the AMRS reports, Figure S3: Geopolitical zonal spread of the Antimicrobial Residue reports, Figure S4a: Level of resistance within generation of antimicrobials tested, Figure S4b: Proportional (%) pattern of resistance levels within generation of antimicrobials tested, Figure S5a: Frequency of Antimicrobial Resistance levels of classes of antib...
27 CitationsSource
#1Aboi Igwaran (University of Fort Hare)H-Index: 5
#2Benson Chuks Iweriebor (University of Fort Hare)H-Index: 9
Last. Anthony I. Okoh (University of Fort Hare)H-Index: 58
view all 3 authors...
Wastewater treatment plants (WWTPs) are designed to eliminate organic matter and pathogens but most WWTPs discharges antimicrobial resistance pathogens into aquatic milieu. The study aimed to examine the antibiotics resistant patterns and the presence of some resistance genes among E. coli isolates from WWTPs effluents. Water were collected from WWTPs final effluents, filtered through nitrocellulose membrane and the filter papers were placed on chromogenic agar plates, incubated for 24 h at 37 °...
22 CitationsSource
#1Nma Bida AlhajiH-Index: 5
#2A.E. HarunaH-Index: 1
Last. T.O. Isola (UI: University of Ibadan)H-Index: 1
view all 5 authors...
Abstract The World Health Organization’s Global Action Plan on antimicrobial resistance (AMR) recommended monitoring of antimicrobial use (AMU) through surveillance and research to help mitigate AMR. This survey was aimed at assessing poultry owners’ knowledge/awareness and practices regarding AMU, identified pathways for AMR emergence and spread in small-scale commercial poultry farms and free-range local bird flocks in North-central Nigeria. An interview questionnaire-based cross-sectional stu...
15 CitationsSource
Cited By29
Newest
#1Yaxin Gu (NWAFU: Northwest A&F University)
#2Zexun Lü (NWAFU: Northwest A&F University)H-Index: 1
Last. Baowei Yang (NWAFU: Northwest A&F University)H-Index: 19
view all 9 authors...
Abstract null null Foodborne disease caused by antibiotic resistant Salmonella is quite difficult to deal with. In order to further explore the antibiotic resistance associated with gene transfer among foodborne Salmonella, several wild-type Salmonella strains were used as donors and recipients, respectively, to investigate how extended spectrum β-lactamases (ESBLs) encoding genes co-transfer with transposable elements to transmit antibiotic resistance. Antibiotic susceptibility was determined b...
Source
#1Maheswaran Easwaran (Kangwon National University)H-Index: 4
#2Juhee Ahn (Kangwon National University)H-Index: 28
The emergence of antibiotic resistance has been raised due to the inappropriate use of antibiotics that might be the urgent health crisis. Antibiotics in animals and food chain have been widely used as growth promoters, prophylaxis, and treatment of infectious diseases, which provides the selective pressure on foodborne pathogens. It is essential to develop novel therapeutic weapon for controlling the appearance of resistance and inhibiting imminent threat of pandemics possible by means of multi...
Source
#1Stephen E. Mshana (SUA: Sokoine University of Agriculture)H-Index: 28
#2Calvin Sindato (SUA: Sokoine University of Agriculture)H-Index: 11
Last. Leonard E. G. Mboera (SUA: Sokoine University of Agriculture)H-Index: 30
view all 4 authors...
In Africa, there is dearth of information on antimicrobial use (AMU) in agriculture and food production systems and its consequential resistance in pathogens that affect animal, human and environmental health. Data published between 1980 and 2021 on the magnitude of AMU and AMR in agriculture and food productions systems in Africa were reviewed. Data from 13–27 countries in Africa indicate that 3558–4279 tonnes of antimicrobials were used in animals from 2015 to 2019. Tetracyclines and polypepti...
Source
#1Zuhura I. Kimera (MUHAS: Muhimbili University of Health and Allied Sciences)H-Index: 2
#2Fauster X Mgaya (MUHAS: Muhimbili University of Health and Allied Sciences)
Last. Mecky I. Matee (SUA: Sokoine University of Agriculture)H-Index: 3
view all 5 authors...
We conducted environmental surveillance of antimicrobial resistance (AMR) bacteria in the Msimbazi river basin in Tanzania to determine the occurrence of extended-spectrum β-lactamase (ESBL)-producing, carbapenem resistant Enterobacteriaceae (CRE) and quinolone resistant Escherichia coli and Klebsiella spp. A total of 213 Enterobacteriaceae isolates were recovered from 219 samples. Out of the recovered isolates, 45.5% (n = 97) were Klebsiella pneumoniae and 29.6% (n = 63) were Escherichia coli. ...
Source
Abstract null null The increase in multidrug-resistant Salmonella enterica and its spread from food to humans are considered a serious public health concern worldwide. Little is currently known about the prevalence of extended-spectrum β-lactamase (ESBL)-producing S. enterica in fish in Africa. Therefore, this study aimed to investigate the existence of ESBL-producing S. enterica in retail fish in Egypt. In total, 200 fish samples were collected randomly from various retail fish markets in Egypt...
1 CitationsSource
#1Raphael Z. Sangeda (MUHAS: Muhimbili University of Health and Allied Sciences)H-Index: 6
Last. Erasto V. Mbugi (MUHAS: Muhimbili University of Health and Allied Sciences)H-Index: 14
view all 9 authors...
Source
#6Stephen E. Mshana (SUA: Sokoine University of Agriculture)H-Index: 28
#9Mecky I. Matee (SUA: Sokoine University of Agriculture)H-Index: 3
We conducted a qualitative study to explore the practices and challenges of veterinary paraprofessionals (paravets) on antimicrobial use and resistance in domestic animals. Methods: This was a qualitative study, which involved semi-structured interviews with paravets from the Ilala, Ubungo, Kigamboni, Kinondoni, and Temeke districts in Dar es Salaam, Tanzania. Results: A total of 40 paravets participated in this study. The majority (72.5%) admitted to having not undergone any formal training on ...
Source
Nanomaterials have been used for diagnosis and therapy in the human medical field, while their application in veterinary medicine and animal production is still relatively new. Nanotechnology, however, is a rapidly growing field, offering the possibility of manufacturing new materials at the nanoscale level, with the formidable potential to revolutionize the agri-food sector by offering novel treatment options for prevalent and expensive illnesses such as bovine mastitis. Since current treatment...
1 CitationsSource
#1Khaled A. El-Tarabily (Murdoch University)H-Index: 24
#2Mohamed T. El-Saadony (Zagazig University)H-Index: 11
Last. Mohamed E. Abd El-Hack (Zagazig University)H-Index: 26
view all 9 authors...
Abstract The increase of resistant bacteria puts a huge pressure on the antimicrobials in current use. Antimicrobial resistance (AMR) results from antibiotic misuse and abuse over many years and is a global financial burden. New polices must be developed for the use of antimicrobials and to continue research efforts to mitigate AMR. It is essential to target the most harmful bacteria and concentrate on their mechanisms of resistance to develop successful antimicrobials. Essential oils (EOs) are ...
9 CitationsSource
Antimicrobial resistance is the failure of antimicrobial’s effect against the growth and multiplication of microorganisms. Imprudent and over antimicrobial use (AMU) aggravates antimicrobial resistance (AMR). Antimicrobials are massively used in animal production as compared with AMU in human health sectors. This research was done with the objective of assessing the knowledge, attitude, and practice (KAP) status of animal producers towards AMU and AMR. A Cross-sectional study design and question...
Source