Targeting Inflammation Driven by HMGB1
Abstract
High mobility group box 1 (HMGB1) is a highly conserved, nuclear protein present in all cell types. It is a multi-facet protein exerting functions both inside and outside of cells. Extracellular HMGB1 has been extensively studied for its prototypical alarmin functions activating innate immunity, after being actively released from cells or passively released upon cell death. TLR4 and RAGE operate as the main HMGB1 receptors. Disulfide HMGB1...
Paper Details
Title
Targeting Inflammation Driven by HMGB1
Published Date
Mar 20, 2020
Journal
Volume
11
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Notes
History