What causes anovulation in polycystic ovary syndrome?

Anovulation in polycystic ovary syndrome (PCOS) is characterised by arrest of antral follicles, a phenotype that can be rescued by increasing circulating concentrations of follicle stimulating hormone (FSH). Abnormalities of gonadotropin regulation, secretion and action have been implicated in the aetiology of anovulation, as well as local, intraovarian factors. Recent studies have implicated both central and intraovarian actions of...