Current Opinion in Endocrine and Metabolic Research
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#1Anna Clapp Organski (Purdue University)
#2Joan S. Jorgensen (UW: University of Wisconsin-Madison)H-Index: 9
Last. Tzu Wen L. Cross (Purdue University)H-Index: 7
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Abstract null null The hypothalamic-pituitary-gonadal (HPG) axis feedback loop is critical in the regulation of the endocrine system. Dysregulation or dysfunction of the HPG axis can impact reproductive, psychiatric, and metabolic health. The gut microbiota is suggested to influence the endocrine system; however, causal effects of the gut microbiota on the HPG axis are unknown. This review summarizes current knowledge of gut microbial influence on components of the HPG axis, including gonadotrop...
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#1Noushin Hadadi (University of Geneva)H-Index: 10
#2Vincent Berweiler (University of Geneva)
Last. Mirko Trajkovski (University of Geneva)H-Index: 15
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Abstract null null The deficiency of micronutrients, including vitamins and minerals, is estimated to affect two billion people worldwide and can have devastating immediate and long-term consequences. Major causes range from inadequate micronutrient consumption mostly owing to a lack of dietary diversity, to poor nutrient absorption in the gastrointestinal tract as a result of clinical or pathological conditions. Recent studies in model organisms and humans demonstrated that intestinal microbiot...
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#1Kylie K. Reed (UNC: University of North Carolina at Chapel Hill)
#2Afrouz AbbaspourH-Index: 4
Last. Ian M. Carroll (UNC: University of North Carolina at Chapel Hill)H-Index: 33
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Abstract null null The intestinal microbiota is a diverse microbial community that colonizes the gastrointestinal tract of animals. Abnormal changes in intestinal microbiota has been associated with multiple diseases including inflammatory bowel diseases and obesity; however, emerging evidence suggests a role for the gut microbiota in anxiety and depression via the gut-brain axis. As this microbial community is associated with weight dysregulation and host behavior it is not surprising that the ...
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#1Amy Pan (MCW: Medical College of Wisconsin)H-Index: 9
Abstract null null Microbiomes not only exist across many different body sites in human beings, but also interact dynamically with the host and environment. The unique feature and complexity of 16S rRNA gene sequence data, especially the sparsity of the data, present challenges to statistical analysis and interpretation. Proper normalization is critical in ensuring the validity of downstream analysis. Modelling the inflated zeros is an active area of research, and it has been extended from diffe...
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#1Lisa Bodei (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 25
#2Mark KiddH-Index: 66
Last. Irvin M. Modlin (Yale University)H-Index: 81
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Abstract null null The recent development of peptide receptor radionuclide therapy (PRRT) into an accepted treatment modality allows for consideration of what needs to be undertaken to move beyond the siege warfare concept of tumor therapy. This chapter therefore seeks to address and resolve the limitations of the “huff and puff” theory of tumor destruction by critically applying the concepts and knowledge of radionuclide therapy. It therefore discusses the advantages of PRRT without ignoring it...
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Abstract null null Endocrine disrupting chemicals (EDCs) that act as xenoestrogens are natural and synthetic chemicals widely present in food products, industrial products, and the environment. Such compounds can activate or inhibit normal hormonal pathways by binding to steroid and non-steroid receptors. It is becomingly apparent that resident bacteria in the gut and elsewhere in the body can dramatically influence host responses. As such, increasing number of studies have examined how EDCs aff...
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#1Maxime Ronot (French Institute of Health and Medical Research)H-Index: 15
#2M.P. Vullierme (University of Paris)H-Index: 4
ABSTRACT Neuroendocrine neoplasms (NENs) predominantly arise within the intestinal tract, pancreas, and lung, but may develop in various organs and commonly metastasize, especially to the liver. Cross-sectional imaging (ultrasound (US), computed tomography (CT) and magnetic resonance [MR] imaging) play a central role in the detection, characterization, management, and follow-up of NENs. Imaging features of tumors significantly vary according to the site of the primary tumor, tumor grade, and dif...
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#1Ariadni Spyroglou (UoA: National and Kapodistrian University of Athens)H-Index: 11
#2Konstantinos Bramis (UoA: National and Kapodistrian University of Athens)H-Index: 13
Last. Krystallenia I. Alexandraki (UoA: National and Kapodistrian University of Athens)H-Index: 29
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Abstract Neuroendocrine neoplasms (NENs) are relatively rare neoplasms. Most NENs are slowly-progressing malignancies with prolonged survival even in the presence of advanced metastatic disease implying an increased need for additional therapies upon failure of those initially administered. However, a subset of NENs may display truly aggressive behavior, often refractory to current chemotherapeutic regimens, underlining the need for more appropriate schemes. Following these unmet needs, new ther...
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#1Susan E. Erdman (MIT: Massachusetts Institute of Technology)H-Index: 38
Abstract The equilibrium between host animals and their microbiota has been convincingly linked with overall host health. Numerous reports describe beneficial effects of probiotic microbiota on the health of humans and other species extending to improved immune functions, wound repair capacity, metabolism, and psychiatry. Among candidate unifying host effector molecules is oxytocin, a neuropeptide hormone related to sociability and a sense of physical and mental well-being. It has been shown in ...
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