Rapid fabrication of collagen bundles mimicking tumor-associated collagen architectures
Abstract
Stromal collagen is upregulated surrounding a solid tumor and presents as dense, thick, linearized, and aligned bundles. The collagen bundles are continually remodeled during tumor progression, and their orientation with respect to the tumor boundary has been correlated with invasive state. Currently, reconstituted-collagen gels are the standard in vitro tumor cell-extracellular matrix interaction model. The reticular, dense, and isotropic...
Paper Details
Title
Rapid fabrication of collagen bundles mimicking tumor-associated collagen architectures
Published Date
May 1, 2020
Journal
Volume
108
Pages
128 - 141
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