Acta Biomaterialia
Papers 7,634
1 page of 764 pages (7,634 results)
#1Duoduo Lu (WMC: Wenzhou Medical University)H-Index: 1
#2Yuemei Han (WMC: Wenzhou Medical University)H-Index: 14
Last. Quankui Lin (WMC: Wenzhou Medical University)H-Index: 16
view all 7 authors...
Abstract null null Posterior capsular opacification (PCO) is the main postoperative complication after intraocular lens (IOL) implantation in cataract surgery, because of the proliferation of the residual lens epithelial cells (LECs) in the lens capsule. Drug-eluting IOLs, aimed to develop an in situ drug delivery device, are the promising concept in recent years. As IOLs are optical devices other than implants, the feasibility and applicability remain a challenge for drug-eluting coatings. In t...
#1Karthik Ramachandran (CIT: California Institute of Technology)H-Index: 6
#2Zixuan Shao (CIT: California Institute of Technology)H-Index: 1
Last. Julia A. Kornfield (CIT: California Institute of Technology)H-Index: 50
view all 13 authors...
Treatment of vascular disease, from peripheral ischemia to coronary heart disease (CHD), is poised for transformation with the introduction of transient implants designed to "scaffold" regeneration of blood vessels and ultimately leave nothing behind. Improved materials could expand the use of these devices. Here, we examine one of the leading polymers for bioresorbable scaffolds (BRS), polylactide (PLA), as the matrix of nanocomposites with tungsten disulfide (WS2) nanotubes (WSNT), which may p...
#1Mulholland Ej (University of Oxford)
#2Emma M. McErlean (QUB: Queen's University Belfast)H-Index: 7
Last. Helen O. McCarthy (QUB: Queen's University Belfast)H-Index: 41
view all 4 authors...
Abstract null null microRNA-31 (miR-31) has been identified to be downregulated in pathologies associated with delayed wound repair. Thus, it was proposed that the delivery of a plasmid encoding miR-31 (pmiR-31) to the skin could hold potential in promoting wound healing. Effective delivery of pmiR-31 was potentiated by encapsulation with the CHAT peptide to form nanocomplexes, this improved cellular entry and elicited a potent increase in miR-31 expression in vitro in both skin human keratinocy...
#1Xiaoyan Sun (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Jiulong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
Last. Xiuli Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 24
view all 10 authors...
Abstract null null The limited infiltration of specific T cells in an immunosuppressive microenvironment is a major challenge for cancer immunotherapy. Reversing tumor microenvironment and inducing an antitumor immune response are crucial for cancer therapy. Here, phenylboronic acid (PBA) derivative-stabilized ultrasmall platinum nanoparticles (PBA-Pt) and dextran-coated BLZ-945 nanoparticles (DNPs) were co-assembled through a pH-responsive borate ester bond to construct a versatile reversible s...
#1Angus Weekes (QUT: Queensland University of Technology)
#2Nicole Bartnikowski (QUT: Queensland University of Technology)H-Index: 9
Last. Travis J. Klein (QUT: Queensland University of Technology)H-Index: 40
view all 6 authors...
Abstract null null Current clinical treatment strategies for the bypassing of small diameter ( null null null Statement of Significance null : Current clinical strategies for the management of cardiovascular disease using small diameter vessel bypassing procedures are inadequate, with up to 75% of synthetic grafts failing within 3 years of implantation. It is this critically important clinical problem that researchers in the field of vascular tissue engineering and regenerative medicine aim to a...
#1Shanshan Ma (Zhengzhou University)H-Index: 8
#2Jiankang Zhou (Zhengzhou University)H-Index: 5
Last. Fangxia Guan (Zhengzhou University)H-Index: 16
view all 12 authors...
#1Kevin M. Beussman (UW: University of Washington)H-Index: 8
#2Molly Y. Mollica (UW: University of Washington)H-Index: 4
Last. Nathan J. SniadeckiH-Index: 30
view all 11 authors...
Abstract null null Measuring the traction forces produced by cells provides insight into their behavior and physiological function. Here, we developed a technique (dubbed ‘black dots’) that microcontact prints a fluorescent micropattern onto a flexible substrate to measure cellular traction forces without constraining cell shape or needing to detach the cells. To demonstrate our technique, we assessed human platelets, which can generate a large range of forces within a population. We find platel...
#1Chengfei Zhao (Putian University)H-Index: 6
#2Xuewen WangH-Index: 6
Last. Shaohuang Weng (FJMU: Fujian Medical University)H-Index: 20
view all 11 authors...
#1Honglian Yu (SWU: Southwest University)H-Index: 1
#2Li Yongcan (SWU: Southwest University)
Last. Peng Xue (SWU: Southwest University)H-Index: 26
view all 8 authors...
Abstract null null Disturbance in redox homeostasis always leads to oxidative damages to cellular components, which inhibits cancer cell proliferation and causes tumor regression. Therefore, synergistic effects arising from cellular redox imbalance together with other treatment modalities are worth further investigation. Herein, a metal-organic framework nanosystem (NMOF) based on coordination between Fe (III) and 4,4,4,4-(porphine-5,10,15,20-tetrayl) tetrakis (benzoic acid) (TCPP) was synthesiz...
#1Shiwei Luo (SCUT: South China University of Technology)H-Index: 2
#2Di Ma (SCUT: South China University of Technology)
Last. Ruimeng Yang (SCUT: South China University of Technology)H-Index: 15
view all 12 authors...
Abstract null null As a promising new form of non-apoptotic regulated cell death, ferroptosis has potential as an effective supplement to apoptosis-based cancer treatments. However, high intracellular glutathione (GSH) levels and insufficient hydrogen peroxide (H2O2) in the tumor limit the efficacy of ferroptosis. Here, we designed a theranostic nanoplatform, named FCS/GCS, by incorporating amphiphilic polymer skeletal (P-SS-D), cinnamaldehyde prodrug (CA-OH) and iron ions (Fe3+)/gadolinium ions...
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