Acta Biomaterialia
Papers 7365
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#1Ilaha Isali (University Hospitals of Cleveland)H-Index: 3
#2Phillip McClellan (Case Western Reserve University)H-Index: 6
Last. Ozan Akkus (Case Western Reserve University)H-Index: 35
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Abstract null null M2 macrophages are associated with deposition of interstitial collagen and other extracellular matrix proteins during the course wound healing and also inflammatory response to biomaterials. Developing advanced biomaterials to promote the M2 subtype may be an effective way to improve tissue reinforcement surgery outcomes. In this study, the effect of genipin, a naturally derived crosslinking agent, on M0 → M2-polarization was investigated. Genipin was introduced either indirec...
#1Ida C. Thaarup (UCPH: University of Copenhagen)H-Index: 1
Last. Thomas Bjarnsholt (Copenhagen University Hospital)H-Index: 69
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Degradable starch microspheres (DSM) have long been used for topical haemostasis, temporary vascular occlusion and as drug delivery systems. When used for the latter, exact degradation rates of DSM have high importance, as this ensures a controlled and timed drug delivery. Current methods of analysing degradation rates are based on whole batch measurements, which does not yield information regarding individual times of degradation nor does it provide direct correlation measurements between spher...
#1Akihiro Nishiguchi (National Institute for Materials Science)H-Index: 14
#2Tetsushi Taguchi (National Institute for Materials Science)H-Index: 24
Decellularized extracellular matrix (dECM) derived from natural ECM is receiving considerable interest as a promising component of tissue adhesives because of its high biocompatibility and tissue regenerative ability. However, the availability of dECM as a tissue adhesive is limited because of the lack of a gelator that can crosslink low concentrations of dECM to form hydrogels. Here, we report dECM-based tissue adhesives using a genipin gelator. Based on the pH-dependent reactivity of genipin, ...
#1Jun Xue (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Shan Zhong (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Liang-Yun Hu (SJTU: Shanghai Jiao Tong University)H-Index: 3
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Abstract null null Radiosensitization is highly desired to reduce side-effect of the harsh dose of radiation therapy (RT), for which nanoparticles with high atomic number elements provide a promising tool. However, insufficient knowledge on utilizing the interaction between nanoparticles and cancerous cells hampers the improvement of therapeutic outcome. We herein employed NaGdF4:Yb,Er nanocrystals as the sensitizer, and modified them with a tumor targeting agent and a mitochondria targeting moi...
#1Adriana Vinhas (University of Minho)H-Index: 3
#2Ana I. Gonçalves (University of Minho)H-Index: 14
Last. Manuela E. Gomes (University of Minho)H-Index: 61
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Abstract null null Cell sheet technology and magnetic based tissue engineering hold the potential to become instrumental in developing magnetically responsive living tissues analogues that can be potentially used both for modelling and therapeutical purposes. Cell sheet constructions more closely recreate physiological niches, through the preservation of contiguous cells and cell-ECM interactions, which assist the cellular guidance in regenerative processes. null We herein propose to use magneti...
#1Manuela Lopera Higuita (Mayo Clinic)H-Index: 3
Last. Leigh G. Griffiths (Mayo Clinic)H-Index: 17
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Diseases of small diameter blood vessels encompass the largest portion of cardiovascular diseases, with over 4.2 million people undergoing autologous vascular grafting every year. However, approximately one third of patients are ineligible for autologous vascular grafting due to lack of suitable donor vasculature. Acellular extracellular matrix (ECM) scaffolds derived from xenogeneic vascular tissue have potential to serve as ideal biomaterials for production of off-the-shelf vascular graft capa...
#1Felipe Eltit (UBC: University of British Columbia)H-Index: 6
#2Jake Noble (Vancouver Prostate Centre)
Last. Nelson V. Greidanus (UBC: University of British Columbia)H-Index: 32
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Abstract null null Adverse local tissue reactions (ALTRs) are a prominent cause of hip implant failure. ALTRs are characterized by aseptic necrosis and leukocyte infiltration of synovial tissue. The prevalence of ALTRs in hips with failing metal implants, with highest rates occurring in patients with metal-on-metal articulations, suggests a role for CoCrMo corrosion in ALTR formation. Although hypersensitivity reactions are the most accepted etiology, the precise cellular mechanism driving ALTR ...
#1Marcos Gil-Garcia (Autonomous University of Barcelona)H-Index: 4
#2Salvador Ventura (Autonomous University of Barcelona)H-Index: 55
Abstract null null Nanostructures decorated with antibodies (Abs) are applied in bioimaging and therapeutics. However, most covalent conjugation strategies affect Abs functionality. In this study, we aimed to create protein-based nanoparticles to which intact Abs can be attached through tight, specific, and noncovalent interactions. Initially considered waste products, bacterial inclusion bodies (IBs) have been used in biotechnology and biomedicine. However, the amyloid-like nature of IBs limits...
#1Malachy Maher (UOW: University of Wollongong)H-Index: 1
#2Miguel Castilho (University Medical Center Utrecht)H-Index: 17
Last. Gordon G. Wallace (UOW: University of Wollongong)H-Index: 127
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Hard tissue engineering has evolved over the past decades, with multiple approaches being explored and developed. Despite the rapid development and success of advanced 3D cell culture, 3D printing technologies and material developments, a gold standard approach to engineering and regenerating hard tissue substitutes such as bone, dentin and cementum, has not yet been realised. One such strategy that differs from conventional regenerative medicine approach of other tissues, is the in vitro minera...
#1Jiawen Chen (Stevens Institute of Technology)
#2Seyed Mohammad Mir (Stevens Institute of Technology)H-Index: 1
Last. Jinho Kim (Stevens Institute of Technology)H-Index: 12
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Abstract null null In living tissues, mechanical stiffness and biological function are intrinsically linked. Alterations in the stiffness of tissues can induce pathological interactions that affect cellular activity and tissue function. Underlying connections between tissue stiffness and disease highlights the importance of accurate quantitative characterizations of soft tissue mechanics, which can improve our understanding of disease and inform therapeutic development. In particular, accurate m...
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