Acta Biomaterialia
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7.24
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6732
Papers 7277
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#1Lidia Fanfoni (UniTS: University of Trieste)H-Index: 8
#2Eleonora Marsich (UniTS: University of Trieste)H-Index: 23
Last. Milena Cadenaro (UniTS: University of Trieste)H-Index: 32
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Abstract Nine antibacterial di-methacrylate monomers based on bis-quaternary ammonium salts (bis-QAMs) were synthesized and structurally characterized. The biological activity of the bis-QAMs was tested in terms of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) on different bacterial strains achieving promising results and, in most cases, a complete bactericidal effect using a bis-QAM concentration lower than 1 mg/mL. Two of the structures showed comparable a...
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#1Longshun Yang (Anda: Anhui University)H-Index: 1
#2Guoqing Yan (Anda: Anhui University)H-Index: 9
Last. Rupei Tang (Anda: Anhui University)H-Index: 20
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Abstract To achieve an ideal drug delivery platform with precise composition and high tumor selectivity, the PEGylated dual-drug backboned prodrug was synthesized via the copolymerization between diamine monomer of ortho ester and cisplatin- demethylcantharidin conjugate (Pt(IV)-1), and then terminated by mPEG550-active ester. The amphipathic prodrug could self-assemble into nano-prodrugs, which endowed the precise structure and high drug loading. Moreover, the nano-prodrugs exhibited physicoche...
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#1H.F. Li (USTB: University of Science and Technology Beijing)H-Index: 20
#2Pengyu Wang (USTB: University of Science and Technology Beijing)
Last. Huang Jinyan (USTB: University of Science and Technology Beijing)
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Abstract Compared with non-degradable metals, biodegradable metals, as a new generation of medical metallic materials, do not require secondary, which reduces the pain and economic burden of patients. However, currently developed biodegradable metals, including iron-based alloys, magnesium-based alloys, and zinc-based alloys, have deficiencies in their corrosion rates and mechanical properties, which have severely restricted the clinical application of biodegradable metals. So there is an urgent...
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#1Brendan D. Stoeckl (UPenn: University of Pennsylvania)H-Index: 2
#2Hannah M. Zlotnick (UPenn: University of Pennsylvania)H-Index: 1
Last. David R. Steinberg (UPenn: University of Pennsylvania)H-Index: 26
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Abstract Given its complex shape and relatively small size, the trapezium surface at the trapeziometacarpal (TMC) joint is a particularly attractive target for anatomic biologic joint resurfacing, especially given its propensity to develop osteoarthritis, and the limited and sub-optimal treatment options available. For this to advance to clinical translation, however, an appropriate large animal model is required. In this study, we explored the porcine accessory carpal bone (ACB) as a model for ...
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#1Miaomiao He (Sichuan University)H-Index: 3
#2Yong Huang (Sichuan University)H-Index: 3
Last. Li Zhang (Sichuan University)H-Index: 32
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Abstract Polyetheretherketone (PEEK) is a popular thermoplastic material widely used in engineering applications due to its favorable mechanical properties and stability at high temperatures. With the first implantable grade PEEK being commercialized in 1990s, the use of PEEK has since grown exponentially in the biomedical field and has rapidly transformed a large section of the medical devices landscape. Nowadays, PEEK is a standard biomaterial used across a wide range of implant applications, ...
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#1Poppy Oldroyd (University of Cambridge)
#2George G. Malliaras (University of Cambridge)H-Index: 79
Abstract Implantable electrodes that can reliably measure brain activity and deliver an electrical stimulus to a target tissue are increasingly employed to treat various neurological diseases and neuropsychiatric disorders. Flexible thin-film electrodes have gained attention over the past few years to minimise invasiveness and damage upon implantation. Research has previously focused on optimising the electrode's electrical and mechanical properties; however, their chronic stability must be vali...
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#1Lindsay Hill (SLU: Saint Louis University)H-Index: 4
#2Joseph Bruns (SLU: Saint Louis University)H-Index: 2
Last. Silviya P. Zustiak (SLU: Saint Louis University)H-Index: 15
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Abstract Glioblastoma multiforme (GBM) is the most aggressive brain tumor with median patient survival of 12-15 months. To facilitate treatment development, bioengineered GBM models that adequately recapitulate the in vivo tumor microenvironment are needed. Matrix-encapsulated multicellular spheroids represent such model because they recapitulate solid tumor characteristics, such as dimensionality, cell-cell, and cell-matrix interactions. Yet, there is no consensus as to which matrix properties ...
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#1Yashaswini Vegi (Swinburne University of Technology)
#2Mirren Charnley (Swinburne University of Technology)H-Index: 16
Last. Nicholas P. Reynolds (Swinburne University of Technology)H-Index: 14
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Abstract Mesenchymal stem cell therapies show great promise in regenerative medicine. However, to generate clinically relevant numbers of these stem cells, significant in vitro expansion of the cells is required before transplantation into the affected wound or defect. The current gold standard protocol for recovering in vitro cultured cells involves treatment with enzymes such as trypsin which can affect the cell phenotype and ability to interact with the environment. Alternative enzyme free me...
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#1Hui Zhu (FAU: University of Erlangen-Nuremberg)
#1Hui Zhu (FAU: University of Erlangen-Nuremberg)H-Index: 5
Last. Aldo R. Boccaccini (FAU: University of Erlangen-Nuremberg)H-Index: 91
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Abstract Mesoporous silica-based materials, especially mesoporous bioactive glasses (MBGs), are being highly considered for biomedical applications, including drug delivery and tissue engineering, not only because of their bioactivity and biocompatibility but also due to their tunable composition and potential use as drug delivery carriers owing to their controllable nanoporous structure. Numerous researches have reported that MBGs can be doped with various therapeutic ions (strontium, copper, m...
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#1Guoru Dai (CPU: China Pharmaceutical University)H-Index: 1
#2Lu Sun (CPU: China Pharmaceutical University)
Last. Wenying Zhong (CPU: China Pharmaceutical University)H-Index: 7
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Hydrogels have drawn considerable attention in the field of drug delivery, yet their poor mechanical strength and uncontrollable drug release behavior have hindered further applications in clinical practice. Taking utility of metal-ligand coordination for structurally reinforcing the hydrogel network, we report design and synthesis of magnetic nanocomposite hydrogels (HA-DOPA•MNPs) that are crosslinked by DOPA-Fe(III) coordination existing between dopamine-conjugated hyaluronan (HA-DOPA) and iro...
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