Effects of an antenatal dietary intervention in women with obesity or overweight on child outcomes at 3–5 years of age: LIMIT randomised trial follow-up

Published on Mar 17, 2020in International Journal of Obesity4.419
· DOI :10.1038/S41366-020-0560-4
Jodie M Dodd50
Estimated H-index: 50
(University of Adelaide),
Andrea R. Deussen16
Estimated H-index: 16
(University of Adelaide),
Jennie Louise11
Estimated H-index: 11
(University of Adelaide)
While the effects of an antenatal dietary intervention for women with obesity or overweight on pregnancy and newborn health have been extensively studied, the longer-term effects into childhood are unknown. We followed children born to women who participated in the LIMIT randomised trial, where pregnant women were randomised to an antenatal dietary and lifestyle intervention or standard antenatal care. Our aim was to assess the effect of the intervention, on child outcomes at 3–5 years of age on children whose mothers provided consent. We assessed 1418 (Lifestyle Advice n = 727; Standard Care n = 691) (66.9%) of the 2121 eligible children. There were no statistically significant differences in the incidence of child BMI z-score >85th centile for children born to women in the Lifestyle Advice Group, compared with the Standard Care group (Lifestyle Advice 444 (41.73%) versus Standard Care 417 (39.51%); adjusted relative risk (aRR) 1.05; 95% confidence intervals 0.93–1.19; p = 0.42). There were no significant effects on measures of child growth, adiposity, neurodevelopment, or dietary intake. There is no evidence that an antenatal dietary intervention altered child growth and adiposity at age 3–5 years. This cohort of children remains at high risk of obesity, and warrants ongoing follow-up.
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