NTRK-rearranged Cervical Sarcoma: Expanding the Clinicopathologic Spectrum

The NTRK genes ( NTRK1 , NTRK2 , and NTRK3 ) encode for TrkA, TrkB, and TrkC, neurotrophic tyrosine receptor kinases which serve a variety of functions including in the regulation of pathways involved in carcinogenesis. A number of reports have described NTRK gene fusions in a variety of adult and pediatric tumor types from various organ systems including the central nervous system, thyroid gland, breast, and soft tissue. NTRK -rearranged...