Original paper
Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Abstract
Epitopes derived from mutated cancer proteins elicit strong antitumor T-cell responses that correlate with clinical efficacy in a proportion of patients. However, it remains unclear whether the subcellular localization of mutated proteins influences the efficiency of T-cell priming. To address this question, we compared the immunogenicity of NY-ESO-1 and OVA localized either in the cytosol or in mitochondria. We showed that tumors expressing...
Paper Details
Title
Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Published Date
Mar 23, 2020
Journal
Volume
8
Issue
5
Pages
685 - 697