Serine Catabolism Feeds NADH when Respiration Is Impaired
Abstract
NADH provides electrons for aerobic ATP production. In cells deprived of oxygen or with impaired electron transport chain activity, NADH accumulation can be toxic. To minimize such toxicity, elevated NADH inhibits the classical NADH-producing pathways: glucose, glutamine, and fat oxidation. Here, through deuterium-tracing studies in cultured cells and mice, we show that folate-dependent serine catabolism also produces substantial NADH....
Paper Details
Title
Serine Catabolism Feeds NADH when Respiration Is Impaired
Published Date
Apr 1, 2020
Journal
Volume
31
Issue
4
Pages
809 - 821.e6
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