Original paper
Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDSs) for senicapoc
Abstract
Senicapoc (SEN), a potent antisickling agent, shows poor water solubility and poor oral bioavailability. To improve the solubility and cell permeation of SEN, self-nanoemulsifying drug delivery systems (SNEDDSs) were developed. Capryol PGMC®, which showed the highest solubilization capacity, was selected as the oil. The self-emulsification ability of two surfactants, viz., Cremophor-EL® and Tween® 80, was compared. Based on a solubility study...
Paper Details
Title
Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDSs) for senicapoc
Published Date
Apr 1, 2020
Volume
580
Pages
119180 - 119180
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Notes
History