The prevalence and etiology of elevated aminotransferase levels in northeastern Taiwan: A community‐based study

Published on Jun 1, 2021in Advances in Digestive Medicine
· DOI :10.1002/AID2.13197
Cheng-Hung Chien7
Estimated H-index: 7
(Memorial Hospital of South Bend),
Chia-Ying Yu5
Estimated H-index: 5
(Memorial Hospital of South Bend)
+ 5 AuthorsRong-Nan Chien21
Estimated H-index: 21
(Memorial Hospital of South Bend)
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Abstract
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References30
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#1Eun-Jeong Joo (SKKU: Sungkyunkwan University)H-Index: 18
#2Yoosoo Chang (SKKU: Sungkyunkwan University)H-Index: 49
Last. Seungho Ryu (SKKU: Sungkyunkwan University)H-Index: 64
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The presence of an association between chronic hepatitis B virus (HBV) infection and fatty liver is controversial. We examined the association between HBV infection and the development of nonalcoholic fatty liver disease (NAFLD). We conducted a cohort study of 83,339 participants without NAFLD at baseline who underwent serologic testing for hepatitis B surface antigen (HBsAg) between 2002 and 2006 and were followed annually or biennially until December 2014. NAFLD was defined as the presence of ...
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#1Sammy Saab (UCLA: University of California, Los Angeles)H-Index: 72
#2Vignan Manne (University of Akron)H-Index: 11
Last. Naga Chalasani (IU: Indiana University)H-Index: 103
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Nonalcoholic fatty liver disease (NAFLD) is a serious public health concern that affects almost one third of the US population. The prevalence of NAFLD varies among ethnic/racial groups, with the Latin American population being affected disproportionately. The severity of NAFLD also may be greater in the Latino population. The increased prevalence and severity of NAFLD in Latino Americans likely is related to the interplay between issues such as genetic factors, access to health care, or the pre...
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#1Zhengtao Liu (Guangxi Medical University)H-Index: 14
#2Yanling Hu (Guangxi Medical University)H-Index: 18
Last. Tao Peng (Guangxi Medical University)H-Index: 22
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Abstract Objectives Abnormal alanine aminotransferase (ALT) activity is indicative of liver disease even a burden of overall health. We assessed the factors associated with ALT activity and their internal relationships in a male population from southern China. Design and methods Data of physical examinations, laboratory tests, hepatic ultrasounds and standardized questionnaire were collected from 2119 males participating in a population-based survey from September 2009 to December 2009. Results ...
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#1Ching-Sheng Hsu (NTU: National Taiwan University)H-Index: 23
#2Jia-Horng Kao (NTU: National Taiwan University)H-Index: 93
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western countries, and has become increasingly recognized as a public health problem in Taiwan. Patients with non-alcoholic steatohepatitis, a more severe form of NAFLD, may progress to cirrhosis and its related complications, including hepatocellular carcinoma. Since NAFLD is highly linked to metabolic syndrome, such patients may have increased risks of complications related to both liver disease and metabolic syndro...
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#1Yuichiro Eguchi (Saga: Saga Group)H-Index: 36
#2Hideyuki Hyogo (Hiroshima University)H-Index: 37
Last. Jsg-Nafld (NARA: National Archives and Records Administration)H-Index: 1
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Background The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. This study aimed to assess the recent prevalence of NAFLD and to predict the prevalence of nonalcoholic steatohepatitis (NASH) with liver fibrosis using established scoring systems in the general population.
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#1Jen Jung Pan (University of Texas Health Science Center at Houston)H-Index: 9
#2Hui-Qi Qu (University of Texas Health Science Center at Houston)H-Index: 28
Last. Michael B. Fallon (University of Texas Health Science Center at Houston)H-Index: 67
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Aim Study the prevalence of metabolic syndrome (MS) and risk factors for and association with elevated alanine aminotransferase (ALT) as markers of hepatic injury in a large Hispanic health disparity cohort with high rates of obesity.
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#1Ann K. Daly (Newcastle University)H-Index: 96
#2Stefano Ballestri (University of Modena and Reggio Emilia)H-Index: 29
Last. Christopher P. Day (Newcastle University)H-Index: 111
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Nonalcoholic fatty liver disease (NAFLD) in most patients involves only simple hepatic steatosis; however, a minority develop progressive steatohepatitis. Family studies and inter-ethnic differences in susceptibility suggest that genetic factors may be important risk determinants for progressive disease. Polymorphisms in genes affecting lipid metabolism, cytokines, fibrotic mediators and oxidative stress may be associated with steatohepatitis and/or fibrosis, but most of these findings require r...
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#1Ji Eun Yun (Yonsei University)H-Index: 21
#2Sang Yeun Kim (Yonsei University)H-Index: 6
Last. Sun Ha Jee (Yonsei University)H-Index: 80
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Background: Few studies have examined the effect of insulin resistance on the association between alanine aminotransferase (ALT) and metabolic syndrome. The association between ALT levels and metabolic syndrome were determined, independently of insulin resistance in Korean populations. Methods and Results: The association between ALT and metabolic syndrome were examined in 28,456 subjects who visited 7 Health Promotion Centers at University Hospitals in Korea from 2006 to 2008. HOMA-IR index was...
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#1Scott J. Cotler (UIC: University of Illinois at Chicago)H-Index: 29
#2Manish K. Dhamija (UIC: University of Illinois at Chicago)H-Index: 3
Last. Shirley S. Wong (UIC: University of Illinois at Chicago)H-Index: 6
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Summary. Alanine aminotransferase (ALT) levels are a primary consideration in treatment decisions regarding hepatitis B virus (HBV) infection. Levels can be elevated as a result of HBV-related liver injury or to other causes. The aim of this study was to assess the background prevalence and clinical correlates of elevated ALT levels in Chinese immigrants who were HBsAg negative. Subjects consisted of adults seen in an urban Chinatown Internal Medicine practice between 1, 2006 and 12, 2007. Clini...
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#1Takafumi Saito (YU: Yamagata University)H-Index: 12
#2Yuko Nishise (YU: Yamagata University)H-Index: 10
Last. Sumio Kawata (YU: Yamagata University)H-Index: 70
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Abstract Measurement of the serum alanine aminotransferase (ALT) level is used as an initial test for detection of liver diseases, and recent studies have also highlighted its potential value as a measure of overall health and survival as a marker of an increased risk of metabolic disorder. This study was designed to clarify the prevalence of elevated ALT levels in the Japanese population and to assess factors associated with ALT elevation. The subjects were 2165 individuals aged 40 to 85 years ...
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#1Pin-Nan Cheng (NCKU: National Cheng Kung University)H-Index: 18
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