Original paper
Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B
Abstract
DNA methyltransferases are primary enzymes for cytosine methylation at CpG sites of epigenetic gene regulation in mammals. De novo methyltransferases DNMT3A and DNMT3B create DNA methylation patterns during development, but how they differentially implement genomic DNA methylation patterns is poorly understood. Here, we report crystal structures of the catalytic domain of human DNMT3B-3L complex, noncovalently bound with and without DNA of...
Paper Details
Title
Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B
Published Date
Feb 19, 2020
Journal
Volume
48
Issue
7
Pages
3949 - 3961