THE ROLE OF 1,25(OH)2D3 AND ITS ANALOGS IN PROLIFERATION AND DIFFERENTIATION OF SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK – LITERATURE REVIEW

Epidemiological studies correlate sun or UV light exposure with a lower incidence of a variety of malignancies, including breast, colon and prostate cancer. The biologically active 1,25(OH)2D3 and its analogs have been shown to have antiproliferative and differentiating effects in a variety of malignant and non-malignant cells. The effects of 1,25(OH)2D3 are mediated by the binding of calcitriol to a specific intracellular receptor, vitamin D...