Ice-templating of chitosan/agarose porous composite hydrogel with adjustable water-sensitive shape memory property and multi-staged degradation performance.

Published on Jun 1, 2020in Colloids and Surfaces B: Biointerfaces4.389
· DOI :10.1016/J.COLSURFB.2020.110907
Kun Yan11
Estimated H-index: 11
,
Feiyang Xu3
Estimated H-index: 3
+ 3 AuthorsDong Wang89
Estimated H-index: 89
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Abstract
Abstract Water-induced shape memory polymers (SMPs) may have important applications in the fields of tissue engineering and biomedicine. However, most of the ideal candidates often suffer from non-biodegradation, weak mechanical strength and random macro-porous structure, which do limit the creativity and dynamism of water-sensitive SPMs. To address above issue, in this study, by incorporating the pH-responsive chitosan (CHIT) into a thermoplastic elastomer agarose (Agar) matrix and ice-templating, a novel dual-responsive interpenetrating polymer network hydrogel with highly porous structure was facilely prepared, which has a ultra-high porosity (> 95%) and water-induced shape recovery ratio (> 90 %, response time
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