Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications

Volume: 79, Issue: 4, Pages: 472 - 480
Published: Feb 10, 2020
Abstract
Autoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of rheumatoid arthritis (RA). The relation between these anti-modified protein antibody (AMPA)-classes is poorly understood as is the ability of different PTM-antigens to activate B-cell receptors (BCRs) directed against citrullinated proteins (CP). Insights into the nature of PTMs able to...
Paper Details
Title
Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications
Published Date
Feb 10, 2020
Volume
79
Issue
4
Pages
472 - 480
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