Short communication: Enhanced autophagy activity in liver tissue of dairy cows with mild fatty liver.

Published on Apr 1, 2020in Journal of Dairy Science3.333
· DOI :10.3168/JDS.2019-17457
Meng Chen1
Estimated H-index: 1
(JLU: Jilin University),
Juan J. Loor68
Estimated H-index: 68
(UIUC: University of Illinois at Urbana–Champaign)
+ 13 AuthorsXinwei Li23
Estimated H-index: 23
(JLU: Jilin University)
ABSTRACT During the transition period, dairy cows are challenged by increased energy demands and decreased dry matter intake, which can induce a variety of metabolic disorders, especially fatty liver. Dairy cows suffering from mild or moderate fatty liver in this period show no distinct clinical symptoms, indicating the occurrence of adaptive processes. The process of autophagy (an adaptive response) leads to degradation of intracellular components to generate energy and maintains cellular homeostasis during negative nutrient status. Whether autophagy is involved in metabolic adaptations of the pathological course of mild fatty liver is unclear. Thus, the aim of this study was to determine hepatic autophagy status in dairy cows with mild fatty liver. Liver samples were collected from healthy cows (n = 15), defined as having hepatic triglyceride (TG) content
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