Juan J. Loor
University of Illinois at Urbana–Champaign
GeneInternal medicineEndocrinologyAnimal scienceGene expressionMolecular biologyTranscriptomeAdipose tissueChemistryIce calvingLactationMammary glandDry matterMethionineLipid metabolismFatty acidBiochemistryMetabolismBiologyImmune system
Publications 510
#1Ming LiH-Index: 8
#2Wei YangH-Index: 8
Last. Xilin Hou
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Fatty liver is a common metabolic disorder afflicting dairy cows during the periparturient period and is closely associated with endoplasmic reticulum (ER) stress. The onset of ER stress in humans and mice alters hepatic lipid metabolism, but it is unknown if such event contributes to fatty liver in dairy cows soon after parturition. ORAI1 is a key component of the store-operated Ca2+ entry mechanism regulating cellular Ca2+ balance. The purpose of this study was to investigate the role of ORAI1...
#1Zhen Shi (JLU: Jilin University)H-Index: 10
#2Yuxiang Song (JLU: Jilin University)H-Index: 8
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
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Disruption of endoplasmic reticulum (ER) homeostasis, a condition termed "ER stress," contributes to the development of liver injury in nonruminants. Because liver injury is a prominent pathological feature associated with overproduction of ketone bodies in dairy cows with ketosis, understanding the ER stress state and its functional consequences on liver injury is of particular interest. Here, 30 multiparous cows (within 3 wk postpartum) classified based on blood β-hydroxybutyrate (BHB) as heal...
#1Wenwen Gao (JLU: Jilin University)H-Index: 5
#2Zhiyuan Fang (JLU: Jilin University)H-Index: 5
Last. Xiliang Du (JLU: Jilin University)H-Index: 12
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Negative energy balance-induced high blood concentrations of free fatty acids during the early postpartum period in dairy cows is a major cause of liver injury. Cows in severe negative energy balance often have suboptimal intakes of feed, which contributes to shortfalls in production of ruminal propionate and circulating glucose. Although increasing propionate production by the rumen through feed additives such as propylene glycol is effective in helping cows alleviate the shortfall in dietary e...
#1Tianle Xu (YZU: Yangzhou University)H-Index: 10
#2Xubin Lu (YZU: Yangzhou University)H-Index: 5
Last. Zhangping Yang (YZU: Yangzhou University)H-Index: 10
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The occurrence of bovine ketosis involves the accumulation of β-hydroxybutyric acid (BHBA), which contributes to the initiation and acceleration of hepatic metabolic stress and inflammation. Metformin has other beneficial effects apart from its medical intervention for diabetes, such as prevention of laminitis and hyper-triglyceridemic. AMPK maintains energy homeostasis and is the intracellular target of metformin action. This study aims to uncover the role of metformin in modulating BHBA-induce...
#1M.G. Lopes (UIUC: University of Illinois at Urbana–Champaign)
#1Matheus Gomes Lopes (UFPEL: Universidade Federal de Pelotas)H-Index: 2
Last. Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
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ABSTRACT Calves born to multiparous Holstein cows fed during the last 30 d of pregnancy 2 different cobalt sources [cobalt glucoheptonate (CoPro) or cobalt pectin (CoPectin)], folic acid (FOA), and rumen-protected methionine (RPM) were used to study neonatal immune responses after ex vivo lipopolysaccharide (LPS) challenge. Groups were (n = 12 calves/group) CoPro, FOA+CoPro, FOA+CoPectin, and FOA+CoPectin+RPM. Calves were weighed at birth and blood collected at birth (before colostrum), 21 d of ...
#1Palombo (UNIMOL: University of Molise)
#1Valentino Palombo (UNIMOL: University of Molise)H-Index: 4
Last. Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
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BACKGROUND Methionine (Met) supply during late-pregnancy enhances fetal development in utero and leads to greater rates of growth during the neonatal period. Due to its central role in coordinating nutrient and one-carbon metabolism along with immune responses of the newborn, the liver could be a key target of the programming effects induced by dietary methyl donors such as Met. To address this hypothesis, liver biopsies from 4-day old calves (n = 6/group) born to Holstein cows fed a control or ...
#1Carlos Fernández (Polytechnic University of Valencia)H-Index: 22
#2T. Romero (Polytechnic University of Valencia)H-Index: 7
Last. Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
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ABSTRACT The aim of this study was to evaluate the effects of incorporating rice straw and orange leaves into the diets for goats. Ten Murciano-Granadina goats at mid lactation weighing 45 ± 0.3 kg were used in a crossover design. Two isoproteic and isoenergetic diets (180 g/kg DM and 17 MJ/kg DM, respectively) with alfalfa hay as forage source (33% of DM) were fed. A control diet (CON) incorporated barley as energy source and soy hulls as fiber component. The experimental diet (ORG) replaced ba...
#1Carlos Fernández (Polytechnic University of Valencia)H-Index: 22
#2Alberto Hernández (Polytechnic University of Valencia)H-Index: 1
Last. Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
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The objective was to determine the effect forage to concentrate (F:C) ratio and stage of lactation on methane emissions, digestibility, nutrient balance, lactation performance, and metabolic responses in lactating goats. Twenty Murciano-Granadina dairy goats were used in an experiment divided into three periods: early (30 d), mid (100 d) and late (170 d) lactation. All goats were fed a diet with 35:65 F:C (FCL) during early-lactation. Then, one group (n = 10 goats) remained on FCL through mid an...
#1M. Vailati-Riboni (UIUC: University of Illinois at Urbana–Champaign)H-Index: 11
#2D.N. Coleman (UIUC: University of Illinois at Urbana–Champaign)H-Index: 8
Last. Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
view all 11 authors...
BACKGROUND We aimed to characterize the protective effects and the molecular mechanisms of action of a Saccharomyces cerevisiae fermentation product (NTK) in response to a mastitis challenge. Eighteen mid-lactation multiparous Holstein cows (n = 9/group) were fed the control diet (CON) or CON supplemented with 19 g/d NTK for 45 d (phase 1, P1) and then infected in the right rear quarter with 2500 CFU of Streptococcus uberis (phase 2, P2). After 36-h, mammary gland and liver biopsies were collect...
#1Hao Zhang (YZU: Yangzhou University)H-Index: 7
#1Hao Zhang (YZU: Yangzhou University)H-Index: 22
Last. Hongrong Wang (YZU: Yangzhou University)H-Index: 10
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BACKGROUND Previous studies demonstrated that dietary l-arginine (Arg) alters the equilibrium between reactive oxygen species (ROS) generation and biological defenses to resist oxidant-induced toxicity. Whether supplying Arg can protect ovine intestinal epithelial cells (OIECs) from hydrogen peroxide (H2O2)-induced oxidative damage is unclear. OBJECTIVES The current study aimed to examine the effect of Arg on mitophagy, mitochondrial dysfunction, and apoptosis induced by H2O2 in OIECs. METHODS T...