Original paper
Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response
Abstract
Hypoxic tumors are refractory to DNA damage drugs. However, the underlying mechanism has yet to be elucidated. We aimed to identify lncRNAs that upregulated under hypoxia and their effects on colorectal cancer (CRC).CRC cells were treated with 1% O2 to identify lncRNAs that upregulated under hypoxia. We integrated these lncRNAs with RNA-seq of 4 paired CRC tissues and TCGA data to get candidate lncRNAs. Multiple in vitro and in vivo assays were...
Paper Details
Title
Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response
Published Date
Jan 21, 2020
Journal
Volume
19
Issue
1