Neuroscience

Chronic stress

Social defeat

Prefrontal cortex

Central nervous system

Biology

Gene

Cognition

Psychology

Nucleus accumbens

Amygdala

Major depressive disorder

Genetics

Biological Psychiatry

Most of our knowledge of the biological basis of major depressive disorder (MDD) is derived from studies of chronic stress models in rodents. While these models capture certain aspects of the behavioral and neuroendocrine features of MDD, the extent to which they reproduce the molecular pathology of the human syndrome remains unknown.

Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models