NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target
Volume: 21, Issue: 3, Pages: 753 - 753
Published: Jan 23, 2020
Abstract
The neurotrophic tropomyosin receptor kinase (NTRK) genes (NTRK1, NTRK2, and NTRK3) code for three transmembrane high-affinity tyrosine-kinase receptors for nerve growth factors (TRK-A, TRK-B, and TRK-C) which are mainly involved in nervous system development. Loss of function alterations in these genes can lead to nervous system development problems; conversely, activating alterations harbor oncogenic potential, promoting cell...
Paper Details
Title
NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target
Published Date
Jan 23, 2020
Volume
21
Issue
3
Pages
753 - 753
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