Review paper
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
Abstract
New biological tools provide new techniques to probe fundamental biological processes. Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which are capable of modulating protein concentrations at a post-translational level by co-opting the ubiquitin-proteasome system. We describe the PROTAC technology and its application to drug discovery and provide examples where PROTACs have enabled novel biological insights....
Paper Details
Title
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
Published Date
Apr 1, 2020
Journal
Volume
181
Issue
1
Pages
102 - 114
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