Original paper
Metabolic dysregulation in the Atp7b −/− Wilson’s disease mouse model
Volume: 117, Issue: 4, Pages: 2076 - 2083
Published: Jan 10, 2020
Abstract
Inactivating mutations in the copper transporter Atp7b result in Wilson's disease. The Atp7b-/- mouse develops hallmarks of Wilson's disease. The activity of several nuclear receptors decreased in Atp7b-/- mice, and nuclear receptors are critical for maintaining metabolic homeostasis. Therefore, we anticipated that Atp7b-/- mice would exhibit altered progression of diet-induced obesity, fatty liver, and insulin resistance. Following 10 wk on a...
Paper Details
Title
Metabolic dysregulation in the Atp7b −/− Wilson’s disease mouse model
Published Date
Jan 10, 2020
Volume
117
Issue
4
Pages
2076 - 2083
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Notes
History