The application of Box-Behnken-Design in the optimization of HPLC separation of fluoroquinolones
Abstract
Box-Behnken Design is a useful tool for the optimization of the chromatographic analysis. The goal of this study was to select the most significant factors that influenced the following parameters of the chromatographic separation: retention time, relative retention time, symmetry of the peaks, tailing factor, a number of theoretical plates, Foley – Dorsey parameter, resolution factor, peak width at half height. The results underwent the ANOVA...
Paper Details
Title
The application of Box-Behnken-Design in the optimization of HPLC separation of fluoroquinolones
Published Date
Dec 19, 2019
Journal
Volume
9
Issue
1
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