Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors

Volume: 26, Issue: 12, Pages: 1151 - 1157
Published: Dec 1, 2019
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and often lethal respiratory illness in humans, and no vaccines or specific treatments are available. Infections are initiated via binding of the MERS-CoV spike (S) glycoprotein to sialosides and dipeptidyl-peptidase 4 (the attachment and entry receptors, respectively). To understand MERS-CoV engagement of sialylated receptors, we determined the cryo-EM structures of S in...
Paper Details
Title
Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors
Published Date
Dec 1, 2019
Volume
26
Issue
12
Pages
1151 - 1157
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