Original paper
Chemoenzymatic Synthesis of Sertraline
Volume: 2020, Issue: 4, Pages: 510 - 513
Published: Dec 11, 2019
Abstract
A chemoenzymatic approach has been developed for the preparation of sertraline, an established anti‐depressant drug. Ketoreductases (KREDs) were employed to yield a key chiral precursor. The bioreduction of the racemic tetralone exhibited excellent enantioselectivity (>99 % ee ) and diastereomeric ratio (99:1) at 29 % conversion (the maximum theoretical yield is 50 %) after 7 hours. The resulting ( S , S )‐alcohol was efficiently oxidized to...
Paper Details
Title
Chemoenzymatic Synthesis of Sertraline
Published Date
Dec 11, 2019
Volume
2020
Issue
4
Pages
510 - 513