Chemoenzymatic Synthesis of Sertraline

Published on Jan 31, 2020in European Journal of Organic Chemistry2.889
· DOI :10.1002/EJOC.201901810
Lisa Marx3
Estimated H-index: 3
(KTH: Royal Institute of Technology),
Nicolás Ríos-Lombardía17
Estimated H-index: 17
+ 4 AuthorsPer Berglund29
Estimated H-index: 29
(KTH: Royal Institute of Technology)
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Abstract
A chemoenzymatic approach has been developed for the preparation of sertraline, an established anti-depressant drug. Ketoreductases (KREDs) were employed to yield a key chiral precursor. The biored ...
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