Original paper
Repression of phagocytosis by human CD33 is not conserved with mouse CD33
Abstract
CD33 is an immunomodulatory receptor linked to Alzheimer’s disease (AD) susceptibility via regulation of phagocytosis in microglia. Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33. The functional consequences of these differences in restraining phagocytosis remains poorly understood. Using a new αmCD33 monoclonal antibody, we show that mCD33 is...
Paper Details
Title
Repression of phagocytosis by human CD33 is not conserved with mouse CD33
Published Date
Dec 3, 2019
Journal
Volume
2
Issue
1