The effect of metal salts on aerosol performance of spray dried carrier-free formulations of levofloxacin.

Published on Jun 1, 2020in DARU2.739
· DOI :10.1007/S40199-019-00317-9
Ahmadreza Barazesh1
Estimated H-index: 1
(Tehran University of Medical Sciences),
Kambiz Gilani26
Estimated H-index: 26
(Tehran University of Medical Sciences)
+ 1 AuthorsMohammad Ali Barghi3
Estimated H-index: 3
(UT: University of Tehran)
Sources
Abstract
Purpose Metal salts are used in formulation of dry powder inhalers (DPIs) for different purposes. Recently the role of these salts in production of small, dense but highly dispersible particles has emerged. In this study the effect of some such salts on dispersibility and respirability of spray dried levofloxacin formulations was evaluated in normal and reduced inhalation air flow or by increasing powder filling in capsules.
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