Gas-exchange and ventilation imaging of COPD in comparison to a healthy cohort using hyperpolarized Xenon-129 MRI

Introduction: Gas-exchange imaging with hyperpolarized Xenon-129 MRI (HPXMRI) is a novel technique with the potential to measure ventilation and gas-exchange abnormalities simultaneously in the lung. A novel numerical model was developed to measure the dynamics of ventilation and gas-exchange simultaneously in COPD patients and healthy subjects. Methods: The HPXMRI gas-exchange images were obtained in 22 subjects; 13 healthy...