Fergus V. Gleeson
Churchill Hospital
CancerInternal medicineRadiologyPET-CTSurgeryMagnetic resonance imagingUltrasoundOncologyArtificial intelligencePositron emission tomographyBiopsyRespiratory diseaseLung cancerPleural diseaseLungDiseaseMalignancyNuclear medicineComputed tomographyMedicine
Publications 374
#1Cheng Xie (John Radcliffe Hospital)
#1Cheng Xie (John Radcliffe Hospital)H-Index: 3
Last. Rajat Chowdhury (NOC: Nuffield Orthopaedic Centre)H-Index: 1
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Scaphoid injuries occult on plain radiography often require further imaging for definitive diagnosis. We investigate the utility of dual-energy computed tomography (DECT) for the detection of acute bone marrow oedema and fracture of scaphoid compared to MRI. Twenty patients who presented acutely (without prior injury) to the emergency department with clinically suspected occult scaphoid fracture and had MRI of the wrist were prospectively recruited to have DECT (GE Revolution CT). Material decom...
1 CitationsSource
#1Daiwei Han (UMCG: University Medical Center Groningen)H-Index: 3
#2Marjolein A Heuvelmans (UMCG: University Medical Center Groningen)H-Index: 17
Last. Rozemarijn Vliegenthart (UMCG: University Medical Center Groningen)H-Index: 24
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To evaluate the performance of a novel convolutional neural network (CNN) for the classification of typical perifissural nodules (PFN). Chest CT data from two centers in the UK and The Netherlands (1668 unique nodules, 1260 individuals) were collected. Pulmonary nodules were classified into subtypes, including “typical PFNs” on-site, and were reviewed by a central clinician. The dataset was divided into a training/cross-validation set of 1557 nodules (1103 individuals) and a test set of 196 nodu...
#1James T GristH-Index: 1
#2Mitchell Chen (Churchill Hospital)H-Index: 5
Last. Fergus V. Gleeson (University of Oxford)H-Index: 57
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Background SARS-CoV-2 targets angiotensin-converting enzyme 2 (ACE2) expressing cells in the respiratory tract. There are reports of breathlessness in patients many months post-infection. Purpose This study aimed to determine if hyperpolarized 129Xe MRI (XeMRI) imaging could identify the possible cause of breathlessness in patients three months after hospital discharge following COVID-19 infection. Materials and Methods This prospective study was undertaken between August and December 2020, with...
1 CitationsSource
#1Mara ArtibaniH-Index: 7
#2Kenta Masuda (University of Oxford)H-Index: 22
Last. Ahmed Ashour AhmedH-Index: 27
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Similar to tumor initiating cells (TICs), minimal residual disease (MRD) is capable of re-initiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here we performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy. We reveal that while MRD cells share important molecular signatures with TICs, they are also characterized ...
#1Eihab O. Bedawi (University of Oxford)H-Index: 5
#2Thomas Moore (University of Oxford)H-Index: 1
Last. Najib M. Rahman (University of Oxford)H-Index: 42
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A 45-year-old Caucasian woman was referred for investigation of recurrent chest infections. She had been treated over the previous 9 months for recurrent symptoms characterised by intermittent episodes of dyspnoea, cough productive of green sputum and pleuritic chest pain. Systemic enquiry was unremarkable; specifically, she had not experienced any weight loss or anorexia. On each episode, oxygen saturations were >94% and heart rate was <100 beats/min, with a single occurrence of a low-grade fev...
#1R. Kim (UPenn: University of Pennsylvania)
Last. Anil Vachani (UPenn: University of Pennsylvania)H-Index: 45
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#1Minsuok KimH-Index: 12
#2Ozkan DoganayH-Index: 5
Last. Fergus V. GleesonH-Index: 57
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Background The full-scale airway network (FAN) flow model shows excellent agreement with limited functional imaging data but requires further validation prior to clinical use. Purpose To validate the ventilation distributions computed with the FAN flow model with xenon ventilation from xenon-enhanced dual-energy (DE) CT in participants with chronic obstructive pulmonary disease (COPD). Materials and Methods In this prospective study, the FAN model extracted structural data from xenon-enhanced DE...
#1Michael J RisteH-Index: 3
#1Michael Riste (University of Oxford)H-Index: 2
Last. Helen McShaneH-Index: 63
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The immunogenicity of the candidate tuberculosis (TB) vaccine MVA85A may be enhanced by aerosol delivery. Intradermal administration was shown to be safe in adults with latent TB infection (LTBI), but data are lacking for aerosol-delivered candidate TB vaccines in this population. We carried out a Phase I trial to evaluate the safety and immunogenicity of MVA85A delivered by aerosol in UK adults with LTBI (NCT02532036). Two volunteers were recruited, and the vaccine was well-tolerated with no sa...
#1Andrew ScarsbrookH-Index: 29
#2Fergus V. GleesonH-Index: 57
Last. Fergus GleesonH-Index: 6
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#1Jamie Franklin (University of Oxford)H-Index: 6
#2A Talwar (University of Oxford)H-Index: 6
Last. Fergus V. Gleeson (University of Oxford)H-Index: 57
view all 7 authors...
AIM To determine the prevalence of pleural abnormalities and describe the computed tomography (CT) features observed in a well-characterised population of patients with pleural infection. MATERIALS AND METHODS A retrospective study of a subgroup of patients from the Second Multi-centre Intra-pleural Sepsis Trial (MIST 2) trial was carried out. Patients were diagnosed with pleural infection on robust clinical criteria. CT examinations were assessed by three observers independently for the presenc...