Fergus V. Gleeson
University of Oxford
CancerInternal medicineRadiologyPET-CTSurgeryPathologyMagnetic resonance imagingUltrasoundOncologyArtificial intelligencePositron emission tomographyBiopsyRespiratory diseaseLung cancerPleural diseaseLungDiseaseMalignancyNuclear medicineComputed tomographyMedicine
Publications 357
#1Karen E. GoochH-Index: 9
#2Trevor R.F. SmithH-Index: 11
Last. Tom TiptonH-Index: 5
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2 CitationsSource
#1J. Bewes (Churchill Hospital)H-Index: 5
#2Ozkan Doganay (Churchill Hospital)
Last. Fergus V. Gleeson (Churchill Hospital)H-Index: 58
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Imaging-based spirometry using hyperpolarized xenon and high-temporal-resolution projection MRI is feasible for determining pulmonary function metrics.
#1Teresa LambeH-Index: 45
Last. Nazia Thakur (Institute for Animal Health)H-Index: 8
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Abstract Vaccines against SARS-CoV-2 are urgently required. Here we report detailed immune profiling after ChAdOx1 nCoV-19 (AZD1222) and subsequent challenge in two animal models of SARS-CoV-2 mediated disease. We demonstrate in rhesus macaques the lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced by prior vaccination with ChAdOx1 nCoV-19 which induced neutralising antibody responses after a single intramuscular administration. In a second animal model, ferrets, ChAdOx1 nCoV-19 r...
This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three of the unvaccinated animals within 10 weeks of challenge, whereas all six vaccinated animals controlled disease for 26 weeks. Three unvaccinated animals limited disease progression, highlighting the intrinsic ability of this macaque species to control diseas...
#1Mara ArtibaniH-Index: 7
#2Kenta Masuda (University of Oxford)H-Index: 22
Last. Ahmed Ashour AhmedH-Index: 28
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Similar to tumor initiating cells (TICs), minimal residual disease (MRD) is capable of re-initiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here we performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy. We reveal that while MRD cells share important molecular signatures with TICs, they are also characterized ...
#1Cheng Xie (John Radcliffe Hospital)H-Index: 3
#1Cheng Xie (John Radcliffe Hospital)
Last. Rajat Chowdhury (NOC: Nuffield Orthopaedic Centre)H-Index: 1
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Scaphoid injuries occult on plain radiography often require further imaging for definitive diagnosis. We investigate the utility of dual-energy computed tomography (DECT) for the detection of acute bone marrow oedema and fracture of scaphoid compared to MRI. Twenty patients who presented acutely (without prior injury) to the emergency department with clinically suspected occult scaphoid fracture and had MRI of the wrist were prospectively recruited to have DECT (GE Revolution CT). Material decom...
2 CitationsSource
#1Daiwei Han (UMCG: University Medical Center Groningen)H-Index: 3
#2Marjolein A Heuvelmans (UMCG: University Medical Center Groningen)H-Index: 17
Last. Rozemarijn Vliegenthart (UMCG: University Medical Center Groningen)H-Index: 37
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To evaluate the performance of a novel convolutional neural network (CNN) for the classification of typical perifissural nodules (PFN). Chest CT data from two centers in the UK and The Netherlands (1668 unique nodules, 1260 individuals) were collected. Pulmonary nodules were classified into subtypes, including “typical PFNs” on-site, and were reviewed by a central clinician. The dataset was divided into a training/cross-validation set of 1557 nodules (1103 individuals) and a test set of 196 nodu...
#1James T GristH-Index: 1
#2Mitchell Chen (Churchill Hospital)H-Index: 5
Last. Fergus V. Gleeson (University of Oxford)H-Index: 58
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Background SARS-CoV-2 targets angiotensin-converting enzyme 2 (ACE2) expressing cells in the respiratory tract. There are reports of breathlessness in patients many months post-infection. Purpose This study aimed to determine if hyperpolarized 129Xe MRI (XeMRI) imaging could identify the possible cause of breathlessness in patients three months after hospital discharge following COVID-19 infection. Materials and Methods This prospective study was undertaken between August and December 2020, with...
5 CitationsSource
#1Eihab O. Bedawi (University of Oxford)H-Index: 5
#2Thomas Moore (University of Oxford)H-Index: 1
Last. Najib M. Rahman (University of Oxford)H-Index: 46
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A 45-year-old Caucasian woman was referred for investigation of recurrent chest infections. She had been treated over the previous 9 months for recurrent symptoms characterised by intermittent episodes of dyspnoea, cough productive of green sputum and pleuritic chest pain. Systemic enquiry was unremarkable; specifically, she had not experienced any weight loss or anorexia. On each episode, oxygen saturations were >94% and heart rate was <100 beats/min, with a single occurrence of a low-grade fev...