Effectiveness of antimicrobial-coated sutures for the prevention of surgical site infection: a review of the literature.

Published on Sep 1, 2018in European Review for Medical and Pharmacological Sciences3.024
· DOI :10.26355/EURREV_201809_15841
Maria Giuseppina Onesti16
Estimated H-index: 16
(Sapienza University of Rome),
Sara Carella8
Estimated H-index: 8
,
Nicolò Scuderi31
Estimated H-index: 31
Source
Abstract
OBJECTIVE: Surgical site infections (SSIs) are the third most common hospital-acquired infections and account for 14% to 16% of all such infections, and suture material may play a role in SSI rate. Given this risk of infection, sutures with antimicrobial activity have been developed. Both in vitro and in vivo experiments have shown that triclosan-coated sutures (TCS) are effective in the prevention of SSIs. Our aim is to analyze currently available RCTs, comparing the effect of antimicrobial-coated suture (ACS) with uncoated suture on the occurrence of SSIs following surgical procedures, we highlighted major contributions of most significant studies and evaluate the current "state of the art" on antimicrobial-coated sutures. MATERIALS AND METHODS: We reviewed 15 RCTs comparing antimicrobial-coated sutures with conventional sutures and assessing the clinical effectiveness of antimicrobial sutures to decrease the risk for SSIs. We focused our attention on each variable in all the analyzed study. RESULTS: Our selected RCTs, produced controversial results: 7 RCTs demonstrated a significant benefit, on the contrary, 8 RCTs presented a comparison in which there was no difference. CONCLUSIONS: On the basis of our selected trial results and the heterogeneous findings of our 7 selected meta-analyses, we conclude that even though the question of whether TCSs could reduce the occurrence of SSI remains still open, the antimicrobial suture was effective in decreasing the risk for postoperative SSIs in a broad population of patients undergoing surgery. Alternative substances are becoming clinically relevant, such as Chlorhexidine (CHX) coated sutures and only 6 in vivo scientific studies evaluated them. In vivo studies, large and comparative clinical research trials are necessary to validate the efficacy of CHX-coated sutures thus allowing their use in clinical practice.
📖 Papers frequently viewed together
22 Citations
49 Citations
References0
Newest
Cited By4
Newest
#2Lilian M. Spencer (Universidad Yachay Tech)H-Index: 6
Last. Frank AlexisH-Index: 30
view all 8 authors...
Suture biomaterials are critical in wound repair by providing support to the healing of different tissues including vascular surgery, hemostasis, and plastic surgery. Important properties of a suture material include physical properties, handling characteristics, and biological response for successful performance. However, bacteria can bind to sutures and become a source of infection. For this reason, there is a need for new biomaterials for suture with antifouling properties. Here we report two...
1 CitationsSource
#1G. F. KopytovH-Index: 4
#2V. V. Malyshko (Kuban State Medical University)H-Index: 1
Last. M. G. Baryshev (KubSU: Kuban State University)H-Index: 1
view all 7 authors...
The paper studies the interaction between surgical catgut and silver nanoparticles depending on the fiber surface treatment and time of exposure (1 and 24 hours) in Ag-containing gels. After a 24-hour exposure, the maximum sorption capacity is observed on polished catgut for silver nanoparticles ranging in size from 1 to 10 nm. After this time period, the sorption capacity of silver nanoparticles on unpolished catgut occurs in Agcontaining gel within the whole size range, mainly from 1 to 5 nm, ...
Source
#1Tianrong Yu (UMCG: University Medical Center Groningen)H-Index: 2
#2Guimei Jiang (UMCG: University Medical Center Groningen)H-Index: 2
Last. Henk J. Busscher (UMCG: University Medical Center Groningen)H-Index: 110
view all 8 authors...
INTRODUCTION Development of new antimicrobials with ever "better" bacterial killing has long been considered the appropriate response to the growing threat of antimicrobial-resistant infections. Nano-antimicrobials have different working mechanisms than antibiotics, including photothermal and enzyme-mimicking properties, high antimicrobial loading, chemical and magnetic targeting abilities, stealth transport through the blood-circulation and enhanced penetration and accumulation in infectious bi...
6 CitationsSource
#1Valentina PucaH-Index: 5
#2Tonino TrainiH-Index: 27
Last. Rossella GrandeH-Index: 22
view all 9 authors...
Surgical site infections (SSIs) represent the most common nosocomial infections, and surgical sutures are optimal surfaces for bacterial adhesion and biofilm formation. Staphylococcus spp., Enterococcus spp., and Escherichia coli are the most commonly isolated microorganisms. The aim of this research was to evaluate the antibiofilm activity of a medical device (MD) containing TIAB, which is a silver-nanotech patented product. The antibacterial effect was evaluated against Staphylococcus aureus A...
3 CitationsSource