Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy
Abstract
Epilepsy is a complex network phenomenon that, as yet, cannot be prevented or cured. We recently proposed network-based approaches to prevent epileptogenesis. For proof of concept we combined two drugs (levetiracetam and topiramate) for which in silico analysis of drug-protein interaction networks indicated a synergistic effect on a large functional network of epilepsy-relevant proteins. Using the intrahippocampal kainate mouse model of temporal...
Paper Details
Title
Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy
Published Date
Feb 1, 2020
Journal
Volume
134
Pages
104664 - 104664
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