Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy

Science56.90
Volume: 366, Issue: 6467, Pages: 881 - 886
Published: Nov 15, 2019
Abstract
Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6-specific T helper (TH)1 and TH17 cells. However, mechanisms governing the cardiotoxicity programming of heart-specific T cells have remained elusive. Using a mouse model of spontaneous autoimmune myocarditis, we show that progression of myocarditis to lethal heart disease depends on cardiac myosin-specific TH17 cells imprinted in the...
Paper Details
Title
Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
Published Date
Nov 15, 2019
Journal
Volume
366
Issue
6467
Pages
881 - 886
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