Original paper
Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice
Abstract
Mammalian focal adhesion proteins Pinch1 and Pinch2 regulate integrin activation and cell-extracellular matrix adhesion and migration. Here, we show that deleting Pinch1 in osteocytes and mature osteoblasts using the 10-kb mouse Dmp1-Cre and Pinch2 globally (double KO; dKO) results in severe osteopenia throughout life, while ablating either gene does not cause bone loss, suggesting a functional redundancy of both factors in bone. Pinch deletion...
Paper Details
Title
Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice
Published Date
Nov 14, 2019
Journal
Volume
4
Issue
22
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Notes
History