Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair

Science56.90
Volume: 366, Issue: 6465, Pages: 589 - 593
Published: Nov 1, 2019
Abstract
Itaconate is an immunometabolite with both anti-inflammatory and bactericidal effects. Its coenzyme A (CoA) derivative, itaconyl-CoA, inhibits B12-dependent methylmalonyl-CoA mutase (MCM) by an unknown mechanism. We demonstrate that itaconyl-CoA is a suicide inactivator of human and Mycobacterium tuberculosis MCM, which forms a markedly air-stable biradical adduct with the 5'-deoxyadenosyl moiety of the B12 coenzyme. Termination of the catalytic...
Paper Details
Title
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair
Published Date
Nov 1, 2019
Journal
Volume
366
Issue
6465
Pages
589 - 593
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