Original paper
Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells
Abstract
The effects of senescence associated secretory phenotype (SASP) from therapy-induced senescent endothelial cells on tumor microenvironment (TME) remains to be clarified. Here, we investigated effects of ionizing radiation (IR)- and doxorubicin-induced senescent HUVEC on TME. MDA-MB-231 cancer cells treated with conditioned medium (CM) from senescent HUVEC or co-cultured with senescent HUVEC significantly increased cancer cell proliferation,...
Paper Details
Title
Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells
Published Date
Oct 1, 2020
Journal
Volume
490
Pages
100 - 110
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Notes
History